Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K

Amphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus Amphidinium. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been fully investigated....

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Autor: Costa i Arnau, Anna M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/220531
Acceso en línea:https://hdl.handle.net/2445/220531
Access Level:acceso abierto
Palabra clave:Química orgànica
Dinoflagel·lades
Organic chemistry
Dinoflagellates
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spelling Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and KCosta i Arnau, Anna M.Química orgànicaDinoflagel·ladesOrganic chemistryDinoflagellatesAmphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus Amphidinium. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been fully investigated. Access to enough material is needed for these studies, but samples of these compounds are limited due to the minute amounts that can only be obtained by either large-scale cultivation of the organism that produces them or by total synthesis. Of all the amphidinolides known to date, only the targets of five of them (B1, H1, J, K, and X) have been examined and all have been found to interact with actin, a crucial cytoskeletal protein. This paper reviews what is currently known about actin-interacting amphidinolides, with a focus on the research of our group. Amphidinolides J and X are F-actin destabilizers, whereas Amphidinolides H1 and K stabilize actin filaments, likely via different mechanisms. More precise details of the interaction between amphidinolides and actin are missing.MDPI2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/220531Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/molecules28135249Molecules, 2023, vol. 28, p. 5249https://doi.org/10.3390/molecules28135249cc-by (c) Costa, A. M., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2205312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
title Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
spellingShingle Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
Costa i Arnau, Anna M.
Química orgànica
Dinoflagel·lades
Organic chemistry
Dinoflagellates
title_short Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
title_full Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
title_fullStr Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
title_full_unstemmed Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
title_sort Actin-Interacting Amphidinolides: Syntheses and Mechanisms of Action of Amphidinolides X, J and K
dc.creator.none.fl_str_mv Costa i Arnau, Anna M.
author Costa i Arnau, Anna M.
author_facet Costa i Arnau, Anna M.
author_role author
dc.subject.none.fl_str_mv Química orgànica
Dinoflagel·lades
Organic chemistry
Dinoflagellates
topic Química orgànica
Dinoflagel·lades
Organic chemistry
Dinoflagellates
description Amphidinolides are a family of more than forty macrolides of varying sizes and complex structures isolated from dinoflagellates of the genus Amphidinium. Although all of them display potent-to-moderate cytotoxicity, their full bioactivity profile and mode of action have not been fully investigated. Access to enough material is needed for these studies, but samples of these compounds are limited due to the minute amounts that can only be obtained by either large-scale cultivation of the organism that produces them or by total synthesis. Of all the amphidinolides known to date, only the targets of five of them (B1, H1, J, K, and X) have been examined and all have been found to interact with actin, a crucial cytoskeletal protein. This paper reviews what is currently known about actin-interacting amphidinolides, with a focus on the research of our group. Amphidinolides J and X are F-actin destabilizers, whereas Amphidinolides H1 and K stabilize actin filaments, likely via different mechanisms. More precise details of the interaction between amphidinolides and actin are missing.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220531
url https://hdl.handle.net/2445/220531
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/molecules28135249
Molecules, 2023, vol. 28, p. 5249
https://doi.org/10.3390/molecules28135249
dc.rights.none.fl_str_mv cc-by (c) Costa, A. M., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Costa, A. M., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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