Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.

10 Páginas.-- 1 Figura.-- 6 Tablas

Detalles Bibliográficos
Autores: Bermúdez-Oria, Alejandra, Rubio-Senent, Fátima, Rodríguez-Gutiérrez, Guillermo, Fernández-Bolaños Guzmán, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/381060
Acceso en línea:http://hdl.handle.net/10261/381060
Access Level:acceso abierto
Palabra clave:Comselogoside (secoiridoid)
β-Cyclodextrin
Antioxidant activity
α-Glucosidase, angiotensin I-converting enzyme (ACE)
In vitro digestion
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spelling Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.Bermúdez-Oria, AlejandraRubio-Senent, FátimaRodríguez-Gutiérrez, GuillermoFernández-Bolaños Guzmán, JuanComselogoside (secoiridoid)β-CyclodextrinAntioxidant activityα-Glucosidase, angiotensin I-converting enzyme (ACE)In vitro digestion10 Páginas.-- 1 Figura.-- 6 TablasThis study explored the impact of complexing comselogoside (COM) with β-cyclodextrin (β-CD) on antioxidant capacity and investigated its in vitro inhibitory effects against α-glucosidase and angiotensin I-converting enzyme (ACE). The COM: β-CD complex in three molar ratios (1:2, 1:1, and 2:1) showed significantly higher antioxidant activity compared to free COM, assessed by DPPH and ferric reducing power assays. COM exhibited weak to moderate α-glucosidase inhibition (IC 1221 μM) and notable ACE inhibition (IC 119.4 μM). Encapsulation improved ACE inhibition notably for the 1:2 and 2:1 M ratios. The cleavage of secoiridoid moiety of COM by β-glucosidase further enhanced ACE inhibition from IC of 63.91 to 41.75 μg/mL in the hydrolysed mixture. In vitro gastrointestinal digestion revealed 34–40% bioaccessibility of COM and its β-CD complex. This study demonstrates the potential of encapsulated COM as a functional food or supplement for preventing and treating diabetes, hypertension, and oxidative stress-related diseases.This study was supported by the Ministerio de Ciencia, Innovación y Universidades of Spain for grants PID2022-142731OB-C21 and MCIN/AEI/http://dx.doi.org/10.13039/501100011033/FEDER, UE.ElsevierMinisterio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520242025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/381060reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142731OB-C21The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.foodchem.2024.140724http://dx.doi.org/10.1016/j.foodchem.2024.140724Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3810602026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
title Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
spellingShingle Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
Bermúdez-Oria, Alejandra
Comselogoside (secoiridoid)
β-Cyclodextrin
Antioxidant activity
α-Glucosidase, angiotensin I-converting enzyme (ACE)
In vitro digestion
title_short Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
title_full Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
title_fullStr Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
title_full_unstemmed Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
title_sort Antioxidant activity and inhibitory effects on angiotensin I-converting enzyme and α-glucosidase of trans-p-coumaroyl-secologanoside (comselogoside) and its inclusion complex with β-cyclodextrin. Bioaccessibility during simulated in vitro gastrointestinal digestion.
dc.creator.none.fl_str_mv Bermúdez-Oria, Alejandra
Rubio-Senent, Fátima
Rodríguez-Gutiérrez, Guillermo
Fernández-Bolaños Guzmán, Juan
author Bermúdez-Oria, Alejandra
author_facet Bermúdez-Oria, Alejandra
Rubio-Senent, Fátima
Rodríguez-Gutiérrez, Guillermo
Fernández-Bolaños Guzmán, Juan
author_role author
author2 Rubio-Senent, Fátima
Rodríguez-Gutiérrez, Guillermo
Fernández-Bolaños Guzmán, Juan
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Comselogoside (secoiridoid)
β-Cyclodextrin
Antioxidant activity
α-Glucosidase, angiotensin I-converting enzyme (ACE)
In vitro digestion
topic Comselogoside (secoiridoid)
β-Cyclodextrin
Antioxidant activity
α-Glucosidase, angiotensin I-converting enzyme (ACE)
In vitro digestion
description 10 Páginas.-- 1 Figura.-- 6 Tablas
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/381060
url http://hdl.handle.net/10261/381060
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142731OB-C21
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1016/j.foodchem.2024.140724
http://dx.doi.org/10.1016/j.foodchem.2024.140724
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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