Genome-wide postnatal changes in immunity following fetal inflammatory response

The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI)...

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Autores: Costa, Daniel, Bonet, Núria, Solé, Amanda, González de Aledo-Castillo, José Manuel, Sabidó Aguadé, Eduard, 1981-, Casals López, Ferran, Rovira, Carlota, Nadal, Alfons, Marin, Jose Luis, Cobo, Teresa, Castelo Valdueza, Robert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/45666
Acceso en línea:http://hdl.handle.net/10230/45666
http://dx.doi.org/10.1111/febs.15578
Access Level:acceso abierto
Palabra clave:Fetal inflammatory response
Postnatal immunity
Preterm birth
Proteomics
Transcriptomics
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spelling Genome-wide postnatal changes in immunity following fetal inflammatory responseCosta, DanielBonet, NúriaSolé, AmandaGonzález de Aledo-Castillo, José ManuelSabidó Aguadé, Eduard, 1981-Casals López, FerranRovira, CarlotaNadal, AlfonsMarin, Jose LuisCobo, TeresaCastelo Valdueza, RobertFetal inflammatory responsePostnatal immunityPreterm birthProteomicsTranscriptomicsThe fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link between prenatal and postnatal systemic inflammation is supported by the presence of well-established inflammatory biomarkers in the umbilical cord and peripheral blood. However, the extent of molecular changes contributing to this association is unknown. Using RNA sequencing and mass spectrometry proteomics, we profiled the transcriptome and proteome of archived neonatal dried blood spot (DBS) specimens from 21 ELGANs. Comparing FIR-affected and unaffected ELGANs, we identified 782 gene and 27 protein expression changes of 50% magnitude or more, and an experiment-wide significance level below 5% false discovery rate. These expression changes confirm the robust postnatal activation of the innate immune system in FIR-affected ELGANs and reveal for the first time an impairment of their adaptive immunity. In turn, the altered pathways provide clues about the molecular mechanisms triggering ISSI after FIR, and the onset of perinatal brain injury. DATABASES: EGAS00001003635 (EGA); PXD011626 (PRIDE).Wiley202020202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/45666http://dx.doi.org/10.1111/febs.15578reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFEBS J. 2021 Apr;288(7):2311-31© 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/456662026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genome-wide postnatal changes in immunity following fetal inflammatory response
title Genome-wide postnatal changes in immunity following fetal inflammatory response
spellingShingle Genome-wide postnatal changes in immunity following fetal inflammatory response
Costa, Daniel
Fetal inflammatory response
Postnatal immunity
Preterm birth
Proteomics
Transcriptomics
title_short Genome-wide postnatal changes in immunity following fetal inflammatory response
title_full Genome-wide postnatal changes in immunity following fetal inflammatory response
title_fullStr Genome-wide postnatal changes in immunity following fetal inflammatory response
title_full_unstemmed Genome-wide postnatal changes in immunity following fetal inflammatory response
title_sort Genome-wide postnatal changes in immunity following fetal inflammatory response
dc.creator.none.fl_str_mv Costa, Daniel
Bonet, Núria
Solé, Amanda
González de Aledo-Castillo, José Manuel
Sabidó Aguadé, Eduard, 1981-
Casals López, Ferran
Rovira, Carlota
Nadal, Alfons
Marin, Jose Luis
Cobo, Teresa
Castelo Valdueza, Robert
author Costa, Daniel
author_facet Costa, Daniel
Bonet, Núria
Solé, Amanda
González de Aledo-Castillo, José Manuel
Sabidó Aguadé, Eduard, 1981-
Casals López, Ferran
Rovira, Carlota
Nadal, Alfons
Marin, Jose Luis
Cobo, Teresa
Castelo Valdueza, Robert
author_role author
author2 Bonet, Núria
Solé, Amanda
González de Aledo-Castillo, José Manuel
Sabidó Aguadé, Eduard, 1981-
Casals López, Ferran
Rovira, Carlota
Nadal, Alfons
Marin, Jose Luis
Cobo, Teresa
Castelo Valdueza, Robert
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fetal inflammatory response
Postnatal immunity
Preterm birth
Proteomics
Transcriptomics
topic Fetal inflammatory response
Postnatal immunity
Preterm birth
Proteomics
Transcriptomics
description The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link between prenatal and postnatal systemic inflammation is supported by the presence of well-established inflammatory biomarkers in the umbilical cord and peripheral blood. However, the extent of molecular changes contributing to this association is unknown. Using RNA sequencing and mass spectrometry proteomics, we profiled the transcriptome and proteome of archived neonatal dried blood spot (DBS) specimens from 21 ELGANs. Comparing FIR-affected and unaffected ELGANs, we identified 782 gene and 27 protein expression changes of 50% magnitude or more, and an experiment-wide significance level below 5% false discovery rate. These expression changes confirm the robust postnatal activation of the innate immune system in FIR-affected ELGANs and reveal for the first time an impairment of their adaptive immunity. In turn, the altered pathways provide clues about the molecular mechanisms triggering ISSI after FIR, and the onset of perinatal brain injury. DATABASES: EGAS00001003635 (EGA); PXD011626 (PRIDE).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/45666
http://dx.doi.org/10.1111/febs.15578
url http://hdl.handle.net/10230/45666
http://dx.doi.org/10.1111/febs.15578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEBS J. 2021 Apr;288(7):2311-31
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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repository.mail.fl_str_mv
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