High-throughput molecular profiling of the fetal inflammatory response in extremely low gestational age newborns
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Preterm newborns require special care for surviving and may develop severe diseases related to prematurity, especially those born very early. The fetal inflammatory response (FIR) to intraamniotic infection is characte...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/671727 |
| Acceso en línea: | http://hdl.handle.net/10803/671727 |
| Access Level: | acceso abierto |
| Palabra clave: | Fetal inflammatory response Preterm birth intraamniotic infection Perinatal brain injury Intermittent or sustained systemic inflammation Part prematur Resposta fetal inflamatòria Infecció intraamniòtica Dany cerebral perinatal Resposta inflamatòria sistèmica 618 |
| Sumario: | Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Preterm newborns require special care for surviving and may develop severe diseases related to prematurity, especially those born very early. The fetal inflammatory response (FIR) to intraamniotic infection is characterized by high levels of cytokines in umbilical cord (UC) blood and it is diagnosed by the identification of pathological vasculitis of vessels of fetal origin in the umbilical cord and the placenta. The FIR jointly with neonatal diseases with systemic inflammation increase the risk of perinatal brain injury. In this thesis we explore the molecular changes associated with FIR in UC and in dried blood spots, collected during the first postnatal week and archived at the newborn screening program, using technologies for high-throughput molecular profiling. The results of this thesis provide new insights into the molecular mechanisms of FIR at birth and postnatally, which can help the identification of biomarkers and therapeutic targets of FIR and FIR-associated disorders |
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