Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease
Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:dadun_______::ba3d402e3653b88f4981b9e7cb505639 |
| Acceso en línea: | https://hdl.handle.net/10171/124463 |
| Access Level: | acceso abierto |
| Palabra clave: | Mediterranean diet Fatty liver Aerobic capacity Oxidative stress Inflammation |
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Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver diseaseMonserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515bQuetglas-Llabrés, M. (Magdalena)|||/items/e01215b2-2b16-4915-a113-aa8e291223a9Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84cMontemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178aMascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fcMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019eSureda, A. (Antoni)|||/items/913957ef-7007-4d48-b143-a6737e4bcfb4Mediterranean dietFatty liverAerobic capacityOxidative stressInflammationBackground: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat content (IFC), levels of oxidative stress, and inflammation biomarkers after a 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) living in the Balearic Islands, Spain, were classified into two groups, according to the adherence to the MedDiet after 6 months of lifestyle intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were measured in plasma and in PBMCs before and after the intervention. Results: Reductions in weight, body mass index, IFC, blood pressure levels, circulating glucose, glycosylated hemoglobin, and markers of liver damage-aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and cytokeratin 18 (CK-18)-were observed after the intervention. The highest reductions were observed in the group with the best adherence to the MedDiet. A significant improvement in cardiorespiratory fitness was also observed in the group with a higher adherence. The activities of catalase in plasma and catalase and superoxide dismutase in blood mononuclear cells increased only in the group with a higher adherence, as well as the catalase gene expression in the blood mononuclear cells. The plasma levels of malondialdehyde and myeloperoxidase decreased, and resolvin-D1 increased in both groups after the intervention, whereas interleukin-6 levels decreased only in the group with a higher adherence to the MedDiet. Conclusions: A greater adherence to the MedDiet is related to greater improvements in IFC, cardiorespiratory fitness, and pro-oxidative and proinflammatory status in NAFLD patients after a 6-month nutritional intervention based on the MedDiet.MDPIDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124463reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::ba3d402e3653b88f4981b9e7cb5056392026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| title |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| spellingShingle |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease Monserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515b Mediterranean diet Fatty liver Aerobic capacity Oxidative stress Inflammation |
| title_short |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| title_full |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| title_fullStr |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| title_full_unstemmed |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| title_sort |
Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease |
| dc.creator.none.fl_str_mv |
Monserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515b Quetglas-Llabrés, M. (Magdalena)|||/items/e01215b2-2b16-4915-a113-aa8e291223a9 Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84c Montemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178a Mascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49 Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190 Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7 Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fc Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Sureda, A. (Antoni)|||/items/913957ef-7007-4d48-b143-a6737e4bcfb4 |
| author |
Monserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515b |
| author_facet |
Monserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515b Quetglas-Llabrés, M. (Magdalena)|||/items/e01215b2-2b16-4915-a113-aa8e291223a9 Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84c Montemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178a Mascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49 Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190 Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7 Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fc Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Sureda, A. (Antoni)|||/items/913957ef-7007-4d48-b143-a6737e4bcfb4 |
| author_role |
author |
| author2 |
Quetglas-Llabrés, M. (Magdalena)|||/items/e01215b2-2b16-4915-a113-aa8e291223a9 Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84c Montemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178a Mascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49 Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190 Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7 Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fc Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Sureda, A. (Antoni)|||/items/913957ef-7007-4d48-b143-a6737e4bcfb4 |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Mediterranean diet Fatty liver Aerobic capacity Oxidative stress Inflammation |
| topic |
Mediterranean diet Fatty liver Aerobic capacity Oxidative stress Inflammation |
| description |
Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat content (IFC), levels of oxidative stress, and inflammation biomarkers after a 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) living in the Balearic Islands, Spain, were classified into two groups, according to the adherence to the MedDiet after 6 months of lifestyle intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were measured in plasma and in PBMCs before and after the intervention. Results: Reductions in weight, body mass index, IFC, blood pressure levels, circulating glucose, glycosylated hemoglobin, and markers of liver damage-aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and cytokeratin 18 (CK-18)-were observed after the intervention. The highest reductions were observed in the group with the best adherence to the MedDiet. A significant improvement in cardiorespiratory fitness was also observed in the group with a higher adherence. The activities of catalase in plasma and catalase and superoxide dismutase in blood mononuclear cells increased only in the group with a higher adherence, as well as the catalase gene expression in the blood mononuclear cells. The plasma levels of malondialdehyde and myeloperoxidase decreased, and resolvin-D1 increased in both groups after the intervention, whereas interleukin-6 levels decreased only in the group with a higher adherence to the MedDiet. Conclusions: A greater adherence to the MedDiet is related to greater improvements in IFC, cardiorespiratory fitness, and pro-oxidative and proinflammatory status in NAFLD patients after a 6-month nutritional intervention based on the MedDiet. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/124463 |
| url |
https://hdl.handle.net/10171/124463 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,812429 |