Increased adherence to the mediterranean diet after lifestyle intervention improves oxidative and inflammatory status in patients with non-alcoholic fatty liver disease

Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat...

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Autores: Monserrat-Mesquida, M. (Margalida)|||/items/3c1bb3a2-8d99-436a-8eed-fd7232e4515b, Quetglas-Llabrés, M. (Magdalena)|||/items/e01215b2-2b16-4915-a113-aa8e291223a9, Bouzas, C. (Cristina)|||/items/ee7406c3-ab99-4d0d-9526-305c39bdf84c, Montemayor, S. (Sofía)|||/items/91594836-00ee-4dcb-bb25-9cde424c178a, Mascaró, C.M. (Catalina M.)|||/items/9577d7ec-2536-4901-b68e-1b6db5edfd49, Casares, M. (Miguel)|||/items/8e73a453-b0c7-4c16-8ecd-b1eb5cdaa190, Llompart, I. (Isabel)|||/items/e603c669-2ecd-41b5-8695-37c3954038a7, Ugarriza, L. (Lucía)|||/items/18cfdc5b-b110-46ce-8c09-c875326947fc, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e, Sureda, A. (Antoni)|||/items/913957ef-7007-4d48-b143-a6737e4bcfb4
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dnet:dadun_______::ba3d402e3653b88f4981b9e7cb505639
Acceso en línea:https://hdl.handle.net/10171/124463
Access Level:acceso abierto
Palabra clave:Mediterranean diet
Fatty liver
Aerobic capacity
Oxidative stress
Inflammation
Descripción
Sumario:Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat content (IFC), levels of oxidative stress, and inflammation biomarkers after a 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) living in the Balearic Islands, Spain, were classified into two groups, according to the adherence to the MedDiet after 6 months of lifestyle intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were measured in plasma and in PBMCs before and after the intervention. Results: Reductions in weight, body mass index, IFC, blood pressure levels, circulating glucose, glycosylated hemoglobin, and markers of liver damage-aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and cytokeratin 18 (CK-18)-were observed after the intervention. The highest reductions were observed in the group with the best adherence to the MedDiet. A significant improvement in cardiorespiratory fitness was also observed in the group with a higher adherence. The activities of catalase in plasma and catalase and superoxide dismutase in blood mononuclear cells increased only in the group with a higher adherence, as well as the catalase gene expression in the blood mononuclear cells. The plasma levels of malondialdehyde and myeloperoxidase decreased, and resolvin-D1 increased in both groups after the intervention, whereas interleukin-6 levels decreased only in the group with a higher adherence to the MedDiet. Conclusions: A greater adherence to the MedDiet is related to greater improvements in IFC, cardiorespiratory fitness, and pro-oxidative and proinflammatory status in NAFLD patients after a 6-month nutritional intervention based on the MedDiet.

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