Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death

Uncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcom...

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Autores: Molina Martín, María, Guerrero Ramos, Félix, Fernández Ruiz, Mario, González Monte, Esther, Cabrera, Jimena, Morales Ruiz, Enrique, Gutiérrez Martínez, Eduardo, Hernández Martínez, Eduardo Rafael, Polanco, Natalia, Hernández Vicente, Ana, Praga Terente, Manuel, Rodríguez Antolín, Alfredo, Pamplona Casamayor, Manuel, Rosa, Federico de la, Cavero, Teresa, Chico, Mario, Villar, Alicia, Justo Alonso, Iago, Andrés Belmonte, Amado
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/98838
Acceso en línea:https://hdl.handle.net/20.500.14352/98838
Access Level:acceso abierto
Palabra clave:617
Clinical research / practice
Donors and donation: donation after brain death (DBD)
Donors and donation: donation after circulatory death (DCD)
Extracorporeal membrane oxygenation (ECMO)
Graft survival
Kidney disease
Kidney transplantation / nephrology
Cirugía
3213 Cirugía
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network_acronym_str ES
network_name_str España
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spelling Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain deathMolina Martín, MaríaGuerrero Ramos, FélixFernández Ruiz, MarioGonzález Monte, EstherCabrera, JimenaMorales Ruiz, EnriqueGutiérrez Martínez, EduardoHernández Martínez, Eduardo RafaelPolanco, NataliaHernández Vicente, AnaPraga Terente, ManuelRodríguez Antolín, AlfredoPamplona Casamayor, ManuelRosa, Federico de laCavero, TeresaChico, MarioVillar, AliciaJusto Alonso, IagoAndrés Belmonte, Amado617Clinical research / practiceDonors and donation: donation after brain death (DBD)Donors and donation: donation after circulatory death (DCD)Extracorporeal membrane oxygenation (ECMO)Graft survivalKidney diseaseKidney transplantation / nephrologyCirugía3213 CirugíaUncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcomes between 237 KT recipients from uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and 237 patients undergoing KT from standard criteria DBD donors during the same period at our institution. We further analyzed risk factors for death-censored graft survival in the uDCD group. Delayed graft function (DGF) was more common in the uDCD group (73.4% vs 46.4%; P < .01), although glomerular filtration rates at the end of follow-up were similar in the 2 groups. uDCD and DBD groups had similar rates for 10-year death-censored graft (82.1% vs 80.4%; P = .623) and recipient survival (86.2% vs 87.6%; P = .454). Donor age >50 years was associated with graft loss in the uDCD group (hazard ratio: 1.91; P = .058), whereas the occurrence of DGF showed no significant effect. uDCD KT under nECMO support resulted in similar graft function and long-term outcomes compared with KT from standard criteria DBD donors. Increased donor age could negatively affect graft survival after uDCD donation.ElsevierUniversidad Complutense de Madrid20182018-06-2720182018-06-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/98838reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/988382026-06-02T12:44:21Z
dc.title.none.fl_str_mv Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
title Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
spellingShingle Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
Molina Martín, María
617
Clinical research / practice
Donors and donation: donation after brain death (DBD)
Donors and donation: donation after circulatory death (DCD)
Extracorporeal membrane oxygenation (ECMO)
Graft survival
Kidney disease
Kidney transplantation / nephrology
Cirugía
3213 Cirugía
title_short Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
title_full Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
title_fullStr Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
title_full_unstemmed Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
title_sort Kidney transplantation from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death
dc.creator.none.fl_str_mv Molina Martín, María
Guerrero Ramos, Félix
Fernández Ruiz, Mario
González Monte, Esther
Cabrera, Jimena
Morales Ruiz, Enrique
Gutiérrez Martínez, Eduardo
Hernández Martínez, Eduardo Rafael
Polanco, Natalia
Hernández Vicente, Ana
Praga Terente, Manuel
Rodríguez Antolín, Alfredo
Pamplona Casamayor, Manuel
Rosa, Federico de la
Cavero, Teresa
Chico, Mario
Villar, Alicia
Justo Alonso, Iago
Andrés Belmonte, Amado
author Molina Martín, María
author_facet Molina Martín, María
Guerrero Ramos, Félix
Fernández Ruiz, Mario
González Monte, Esther
Cabrera, Jimena
Morales Ruiz, Enrique
Gutiérrez Martínez, Eduardo
Hernández Martínez, Eduardo Rafael
Polanco, Natalia
Hernández Vicente, Ana
Praga Terente, Manuel
Rodríguez Antolín, Alfredo
Pamplona Casamayor, Manuel
Rosa, Federico de la
Cavero, Teresa
Chico, Mario
Villar, Alicia
Justo Alonso, Iago
Andrés Belmonte, Amado
author_role author
author2 Guerrero Ramos, Félix
Fernández Ruiz, Mario
González Monte, Esther
Cabrera, Jimena
Morales Ruiz, Enrique
Gutiérrez Martínez, Eduardo
Hernández Martínez, Eduardo Rafael
Polanco, Natalia
Hernández Vicente, Ana
Praga Terente, Manuel
Rodríguez Antolín, Alfredo
Pamplona Casamayor, Manuel
Rosa, Federico de la
Cavero, Teresa
Chico, Mario
Villar, Alicia
Justo Alonso, Iago
Andrés Belmonte, Amado
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617
Clinical research / practice
Donors and donation: donation after brain death (DBD)
Donors and donation: donation after circulatory death (DCD)
Extracorporeal membrane oxygenation (ECMO)
Graft survival
Kidney disease
Kidney transplantation / nephrology
Cirugía
3213 Cirugía
topic 617
Clinical research / practice
Donors and donation: donation after brain death (DBD)
Donors and donation: donation after circulatory death (DCD)
Extracorporeal membrane oxygenation (ECMO)
Graft survival
Kidney disease
Kidney transplantation / nephrology
Cirugía
3213 Cirugía
description Uncontrolled donation after circulatory death (uDCD) increases organ availability for kidney transplant (KT) with short-term outcomes similar to those obtained from donation after brain death (DBD) donors. However, heterogeneous results in the long term have been reported. We compared 10-year outcomes between 237 KT recipients from uDCD donors maintained by normothermic extracorporeal membrane oxygenation (nECMO) and 237 patients undergoing KT from standard criteria DBD donors during the same period at our institution. We further analyzed risk factors for death-censored graft survival in the uDCD group. Delayed graft function (DGF) was more common in the uDCD group (73.4% vs 46.4%; P < .01), although glomerular filtration rates at the end of follow-up were similar in the 2 groups. uDCD and DBD groups had similar rates for 10-year death-censored graft (82.1% vs 80.4%; P = .623) and recipient survival (86.2% vs 87.6%; P = .454). Donor age >50 years was associated with graft loss in the uDCD group (hazard ratio: 1.91; P = .058), whereas the occurrence of DGF showed no significant effect. uDCD KT under nECMO support resulted in similar graft function and long-term outcomes compared with KT from standard criteria DBD donors. Increased donor age could negatively affect graft survival after uDCD donation.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-27
2018
2018-06-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/98838
url https://hdl.handle.net/20.500.14352/98838
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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