Regiodivergent Deuteration of Pyridine-Based Heterocycles
Herein, we describe a regiodivergent deuteration of pyridotriazoles under mild conditions. Site-selective deuteration can be tuned, controlled, and switched by a subtle interplay of the base and solvent utilized. Given the ease at which pyridotriazoles can be converted into a variety of pyridine con...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/487540 |
| Acceso en línea: | http://hdl.handle.net/2072/487540 https://doi.org/10.1021/acs.orglett.5c02961 |
| Access Level: | acceso abierto |
| Palabra clave: | Química 54 |
| Sumario: | Herein, we describe a regiodivergent deuteration of pyridotriazoles under mild conditions. Site-selective deuteration can be tuned, controlled, and switched by a subtle interplay of the base and solvent utilized. Given the ease at which pyridotriazoles can be converted into a variety of pyridine congeners, this protocol might offer a new gateway to access a variety of deuterium-labeled pyridine-containing heterocycles in a site-selective, yet predictable, manner. |
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