Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study

Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce t...

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Autores: Pérez-Recio, Sandra, Grijota-Camino, Maria D, Anibarro, Luis, Rabuñal-Rey, Ramón, Sabria, Josefina, Gijón-Vidaurreta, Paloma, Pomar, Virginia, García-Gasalla, Mercedes, Domínguez-Castellano, Ángel, Trigo, Matilde, Santos, María Jesús, Cebollero, Alba, Rodríguez, Sara, Moga, Esther, Penas-Truque, Anton, Martos, Carmen, Ruiz-Serrano, M Jesús, Garcia-de-Cara, Erika I, Alcaide Matas, Fernando, Santin, Miguel
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19966
Acceso en línea:https://hdl.handle.net/20.500.13003/19966
Access Level:acceso abierto
Palabra clave:Prospective Studies
Adult
Tuberculosis
Tuberculosis, Pulmonary
Humans
Cohort Studies
Latent Tuberculosis
Tuberculosis Latente
Tuberculosis Pulmonar
Estudios de Cohortes
Humanos
Estudios Prospectivos
Adulto
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spelling Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort studyPérez-Recio, SandraGrijota-Camino, Maria DAnibarro, LuisRabuñal-Rey, RamónSabria, JosefinaGijón-Vidaurreta, PalomaPomar, VirginiaGarcía-Gasalla, MercedesDomínguez-Castellano, ÁngelTrigo, MatildeSantos, María JesúsCebollero, AlbaRodríguez, SaraMoga, EstherPenas-Truque, AntonMartos, CarmenRuiz-Serrano, M JesúsGarcia-de-Cara, Erika IAlcaide Matas, FernandoSantin, MiguelProspective StudiesAdultTuberculosisTuberculosis, PulmonaryHumansCohort StudiesLatent TuberculosisTuberculosis LatenteTuberculosis PulmonarEstudios de CohortesTuberculosisHumanosEstudios ProspectivosAdultoInterferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.Plos20232023-01-0120232023-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19966reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/199662026-06-22T12:44:07Z
dc.title.none.fl_str_mv Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
title Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
spellingShingle Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
Pérez-Recio, Sandra
Prospective Studies
Adult
Tuberculosis
Tuberculosis, Pulmonary
Humans
Cohort Studies
Latent Tuberculosis
Tuberculosis Latente
Tuberculosis Pulmonar
Estudios de Cohortes
Tuberculosis
Humanos
Estudios Prospectivos
Adulto
title_short Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
title_full Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
title_fullStr Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
title_full_unstemmed Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
title_sort Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study
dc.creator.none.fl_str_mv Pérez-Recio, Sandra
Grijota-Camino, Maria D
Anibarro, Luis
Rabuñal-Rey, Ramón
Sabria, Josefina
Gijón-Vidaurreta, Paloma
Pomar, Virginia
García-Gasalla, Mercedes
Domínguez-Castellano, Ángel
Trigo, Matilde
Santos, María Jesús
Cebollero, Alba
Rodríguez, Sara
Moga, Esther
Penas-Truque, Anton
Martos, Carmen
Ruiz-Serrano, M Jesús
Garcia-de-Cara, Erika I
Alcaide Matas, Fernando
Santin, Miguel
author Pérez-Recio, Sandra
author_facet Pérez-Recio, Sandra
Grijota-Camino, Maria D
Anibarro, Luis
Rabuñal-Rey, Ramón
Sabria, Josefina
Gijón-Vidaurreta, Paloma
Pomar, Virginia
García-Gasalla, Mercedes
Domínguez-Castellano, Ángel
Trigo, Matilde
Santos, María Jesús
Cebollero, Alba
Rodríguez, Sara
Moga, Esther
Penas-Truque, Anton
Martos, Carmen
Ruiz-Serrano, M Jesús
Garcia-de-Cara, Erika I
Alcaide Matas, Fernando
Santin, Miguel
author_role author
author2 Grijota-Camino, Maria D
Anibarro, Luis
Rabuñal-Rey, Ramón
Sabria, Josefina
Gijón-Vidaurreta, Paloma
Pomar, Virginia
García-Gasalla, Mercedes
Domínguez-Castellano, Ángel
Trigo, Matilde
Santos, María Jesús
Cebollero, Alba
Rodríguez, Sara
Moga, Esther
Penas-Truque, Anton
Martos, Carmen
Ruiz-Serrano, M Jesús
Garcia-de-Cara, Erika I
Alcaide Matas, Fernando
Santin, Miguel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Prospective Studies
Adult
Tuberculosis
Tuberculosis, Pulmonary
Humans
Cohort Studies
Latent Tuberculosis
Tuberculosis Latente
Tuberculosis Pulmonar
Estudios de Cohortes
Tuberculosis
Humanos
Estudios Prospectivos
Adulto
topic Prospective Studies
Adult
Tuberculosis
Tuberculosis, Pulmonary
Humans
Cohort Studies
Latent Tuberculosis
Tuberculosis Latente
Tuberculosis Pulmonar
Estudios de Cohortes
Tuberculosis
Humanos
Estudios Prospectivos
Adulto
description Interferon-y Release Assays (IGRA) reversions have been reported in different clinical scenarios for the diagnosis of tuberculosis (TB) infection. This study aimed to determine the rate of QuantiFERON-TB Gold Plus (QFT-Plus) reversions during contact investigation as a potential strategy to reduce the number of preventive treatments. Prospective, multicentre cohort study of immunocompetent adult contacts of patients with pulmonary TB tested with QFT-Plus. Contacts with an initial positive QFT-Plus (QFT-i) underwent a second test within 4 weeks (QFT-1), and if negative, underwent a repeat test 4 weeks later (QFT-2). Based on the QFT-2 result, we classified cases as sustained reversion if they remained negative and as temporary reversion if they turned positive. We included 415 contacts, of whom 96 (23.1%) had an initial positive test (QFT-i). Following this, 10 had negative QFT-1 results and 4 (4.2%) of these persisted with a negative result in the QFT-2 (sustained reversions). All four sustained reversions occurred in contacts with IFN-γ concentrations between ≥0.35 and ≤0.99 IU•mL-1 in one or both QFT-i tubes. In this study, TB contact investigations rarely reveal QFT-Plus reversion. These results do not support retesting cases with an initial positive result to reduce the number of preventive treatments.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19966
url https://hdl.handle.net/20.500.13003/19966
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Plos
publisher.none.fl_str_mv Plos
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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