Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats

We aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. Thus, the offspring of: dams fed standard-diet (SD) (CON...

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Detalles Bibliográficos
Autores: Castillo, Pedro, Pomar, Catalina Amadora, Palou, Andreu, Palou, Mariona, Picó, Catalina
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23692
Acceso en línea:https://hdl.handle.net/20.500.12105/23692
Access Level:acceso abierto
Palabra clave:Animales
Fenómenos Fisiologicos Nutricionales Maternos
Femenino
Dieta
Masculino
Ratas
Lactancia
Obesidad
Embarazo
Parto
Leptina
Efectos Tardíos de la Exposición Prenatal
Adiposidad
Maternal Nutritional Physiological Phenomena
Obesity
Lactation
Pregnancy
Male
Diet
Parturition
Leptin
Female
Rats
Animals
Adiposity
Prenatal Exposure Delayed Effects
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network_acronym_str ES
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repository_id_str
spelling Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in RatsCastillo, PedroPomar, Catalina AmadoraPalou, AndreuPalou, MarionaPicó, CatalinaAnimalesFenómenos Fisiologicos Nutricionales MaternosFemeninoDietaMasculinoRatasLactanciaObesidadEmbarazoPartoLeptinaEfectos Tardíos de la Exposición PrenatalAdiposidadMaternal Nutritional Physiological PhenomenaObesityLactationPregnancyMaleDietParturitionLeptinFemaleRatsAnimalsAdiposityPrenatal Exposure Delayed EffectsWe aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. Thus, the offspring of: dams fed standard-diet (SD) (CON-dams), dams fed western-diet (WD) before and during gestation and lactation (WD-dams), and dams fed as WD-dams but moved to SD during lactation (REV-dams) were supplemented throughout suckling with leptin or vehicle, and fed SD or WD from weaning to four months. Under SD, leptin treatment significantly improved metabolic profile and body fat accumulation, with stronger effects in the male offspring of CON-dams and REV-dams. Under WD, the offspring of WD-dams presented metabolic alterations that were not evident in the offspring of REV-dams. Moreover, leptin supplementation improved glucose homeostasis in the male offspring of REV-dams. Conversely, leptin supplementation in females born to WD-dams and fed WD from weaning resulted in impaired insulin sensitivity and increased hepatic lipid content. These results highlight the importance of a balanced maternal diet during the perinatal period, especially lactation, for the subsequent metabolic health of the offspring and for the beneficial effects of leptin supplementation during suckling, more evident in the male offspring.Multidisciplinary Digital Publishing Institute (MDPI)20242024-10-0920232023-01-2120232023-01-21research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23692reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/236922026-06-12T12:43:37Z
dc.title.none.fl_str_mv Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
title Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
spellingShingle Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
Castillo, Pedro
Animales
Fenómenos Fisiologicos Nutricionales Maternos
Femenino
Dieta
Masculino
Ratas
Lactancia
Obesidad
Embarazo
Parto
Leptina
Efectos Tardíos de la Exposición Prenatal
Adiposidad
Maternal Nutritional Physiological Phenomena
Obesity
Lactation
Pregnancy
Male
Diet
Parturition
Leptin
Female
Rats
Animals
Adiposity
Prenatal Exposure Delayed Effects
title_short Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
title_full Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
title_fullStr Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
title_full_unstemmed Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
title_sort Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
dc.creator.none.fl_str_mv Castillo, Pedro
Pomar, Catalina Amadora
Palou, Andreu
Palou, Mariona
Picó, Catalina
author Castillo, Pedro
author_facet Castillo, Pedro
Pomar, Catalina Amadora
Palou, Andreu
Palou, Mariona
Picó, Catalina
author_role author
author2 Pomar, Catalina Amadora
Palou, Andreu
Palou, Mariona
Picó, Catalina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Animales
Fenómenos Fisiologicos Nutricionales Maternos
Femenino
Dieta
Masculino
Ratas
Lactancia
Obesidad
Embarazo
Parto
Leptina
Efectos Tardíos de la Exposición Prenatal
Adiposidad
Maternal Nutritional Physiological Phenomena
Obesity
Lactation
Pregnancy
Male
Diet
Parturition
Leptin
Female
Rats
Animals
Adiposity
Prenatal Exposure Delayed Effects
topic Animales
Fenómenos Fisiologicos Nutricionales Maternos
Femenino
Dieta
Masculino
Ratas
Lactancia
Obesidad
Embarazo
Parto
Leptina
Efectos Tardíos de la Exposición Prenatal
Adiposidad
Maternal Nutritional Physiological Phenomena
Obesity
Lactation
Pregnancy
Male
Diet
Parturition
Leptin
Female
Rats
Animals
Adiposity
Prenatal Exposure Delayed Effects
description We aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. Thus, the offspring of: dams fed standard-diet (SD) (CON-dams), dams fed western-diet (WD) before and during gestation and lactation (WD-dams), and dams fed as WD-dams but moved to SD during lactation (REV-dams) were supplemented throughout suckling with leptin or vehicle, and fed SD or WD from weaning to four months. Under SD, leptin treatment significantly improved metabolic profile and body fat accumulation, with stronger effects in the male offspring of CON-dams and REV-dams. Under WD, the offspring of WD-dams presented metabolic alterations that were not evident in the offspring of REV-dams. Moreover, leptin supplementation improved glucose homeostasis in the male offspring of REV-dams. Conversely, leptin supplementation in females born to WD-dams and fed WD from weaning resulted in impaired insulin sensitivity and increased hepatic lipid content. These results highlight the importance of a balanced maternal diet during the perinatal period, especially lactation, for the subsequent metabolic health of the offspring and for the beneficial effects of leptin supplementation during suckling, more evident in the male offspring.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-21
2023
2023-01-21
2024
2024-10-09
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23692
url https://hdl.handle.net/20.500.12105/23692
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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