In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies

Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal,...

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Autores: Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282, Pagliazzi, Marco, Negredo Puigmal, Eugènia|||0000-0001-5298-1734, Martelli, Fabrizio, Farina, Andrea, Dalla Mora, Alberto, Lindner, Claus|||0000-0002-9878-037X, Farzam, Parisa, Pérez-Álvarez, Núria|||0000-0001-6582-1553, Puig, Jordi|||0000-0002-4075-0346, Taroni, Paola, Pifferi, Antonio, Durduran, Turgut|||0000-0001-5838-1027
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:254279
Acceso en línea:https://ddd.uab.cat/record/254279
https://dx.doi.org/urn:doi:10.1371/journal.pone.0168426
Access Level:acceso abierto
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spelling In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation SpectroscopiesKonugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282Pagliazzi, MarcoNegredo Puigmal, Eugènia|||0000-0001-5298-1734Martelli, FabrizioFarina, AndreaDalla Mora, AlbertoLindner, Claus|||0000-0002-9878-037XFarzam, ParisaPérez-Álvarez, Núria|||0000-0001-6582-1553Puig, Jordi|||0000-0002-4075-0346Taroni, PaolaPifferi, AntonioDurduran, Turgut|||0000-0001-5838-1027Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/254279https://dx.doi.org/urn:doi:10.1371/journal.pone.0168426reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 317526Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-64465-C2-1-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2542792026-06-06T12:50:31Z
dc.title.none.fl_str_mv In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
title In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
spellingShingle In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282
title_short In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
title_full In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
title_fullStr In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
title_full_unstemmed In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
title_sort In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies
dc.creator.none.fl_str_mv Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282
Pagliazzi, Marco
Negredo Puigmal, Eugènia|||0000-0001-5298-1734
Martelli, Fabrizio
Farina, Andrea
Dalla Mora, Alberto
Lindner, Claus|||0000-0002-9878-037X
Farzam, Parisa
Pérez-Álvarez, Núria|||0000-0001-6582-1553
Puig, Jordi|||0000-0002-4075-0346
Taroni, Paola
Pifferi, Antonio
Durduran, Turgut|||0000-0001-5838-1027
author Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282
author_facet Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282
Pagliazzi, Marco
Negredo Puigmal, Eugènia|||0000-0001-5298-1734
Martelli, Fabrizio
Farina, Andrea
Dalla Mora, Alberto
Lindner, Claus|||0000-0002-9878-037X
Farzam, Parisa
Pérez-Álvarez, Núria|||0000-0001-6582-1553
Puig, Jordi|||0000-0002-4075-0346
Taroni, Paola
Pifferi, Antonio
Durduran, Turgut|||0000-0001-5838-1027
author_role author
author2 Pagliazzi, Marco
Negredo Puigmal, Eugènia|||0000-0001-5298-1734
Martelli, Fabrizio
Farina, Andrea
Dalla Mora, Alberto
Lindner, Claus|||0000-0002-9878-037X
Farzam, Parisa
Pérez-Álvarez, Núria|||0000-0001-6582-1553
Puig, Jordi|||0000-0002-4075-0346
Taroni, Paola
Pifferi, Antonio
Durduran, Turgut|||0000-0001-5838-1027
author2_role author
author
author
author
author
author
author
author
author
author
author
author
description Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/254279
https://dx.doi.org/urn:doi:10.1371/journal.pone.0168426
url https://ddd.uab.cat/record/254279
https://dx.doi.org/urn:doi:10.1371/journal.pone.0168426
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 317526
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-64465-C2-1-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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