In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies

Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal,...

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Detalles Bibliográficos
Autores: Konugolu Venkata Sekar, Sanathana|||0000-0003-0912-1282, Pagliazzi, Marco, Negredo Puigmal, Eugènia|||0000-0001-5298-1734, Martelli, Fabrizio, Farina, Andrea, Dalla Mora, Alberto, Lindner, Claus|||0000-0002-9878-037X, Farzam, Parisa, Pérez-Álvarez, Núria|||0000-0001-6582-1553, Puig, Jordi|||0000-0002-4075-0346, Taroni, Paola, Pifferi, Antonio, Durduran, Turgut|||0000-0001-5838-1027
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:254279
Acceso en línea:https://ddd.uab.cat/record/254279
https://dx.doi.org/urn:doi:10.1371/journal.pone.0168426
Access Level:acceso abierto
Descripción
Sumario:Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.

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