Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.

Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain magnetic resonance images from 23 isolated no...

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Autores: Benkarim OM, Hahner N, Piella G, Gratacos E, Gonzalez Ballester MA, Eixarch E, Sanroma G
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p13543
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13543
Access Level:acceso abierto
Palabra clave:*Cortical folding
*Fetal brain
*Lasso
*MRI
*Statistical analysis
*Ventriculomegaly
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spelling Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.Benkarim OMHahner NPiella GGratacos EGonzalez Ballester MAEixarch ESanroma G*Cortical folding*Fetal brain*Lasso*MRI*Statistical analysis*VentriculomegalyNeuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain magnetic resonance images from 23 isolated non-severe ventriculomegaly (INSVM) fetuses and 25 healthy controls between 26 and 29 gestational weeks were used to identify INSVM-related cortical folding deviations from normative development. Since these alterations may reflect abnormal neurodevelopment, our working hypothesis is that markers of cortical folding can provide cues to improve the prediction of later neurodevelopmental problems in INSVM subjects. We analyzed the relationship of ventricular enlargement with cortical folding alterations in a regional basis using several curvature-based measures describing the folding of each cortical region. Statistical analysis (global and hemispheric) and sparse linear regression approaches were then used to find the cortical regions whose folding is associated with ventricular dilation. Results from both approaches were in great accordance, showing a significant cortical folding decrease in the insula, posterior part of the temporal lobe and occipital lobe. Moreover, compared to the global analysis, stronger ipsilateral associations of ventricular enlargement with reduced cortical folding were encountered by the hemispheric analysis. Our findings confirm and extend previous studies by identifying various cortical regions and emphasizing ipsilateral effects of ventricular enlargement in altered folding. This suggests that INSVM is an indicator of altered cortical development, and moreover, cortical regions with reduced folding constitute potential prognostic biomarkers to be used in follow-up studies to decipher the outcome of INSVM fetuses.ELSEVIER SCI LTD2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13543NeuroImage-ClinicalISSN: 22131582reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p135432026-05-27T12:37:41Z
dc.title.none.fl_str_mv Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
title Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
spellingShingle Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
Benkarim OM
*Cortical folding
*Fetal brain
*Lasso
*MRI
*Statistical analysis
*Ventriculomegaly
title_short Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
title_full Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
title_fullStr Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
title_full_unstemmed Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
title_sort Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly.
dc.creator.none.fl_str_mv Benkarim OM
Hahner N
Piella G
Gratacos E
Gonzalez Ballester MA
Eixarch E
Sanroma G
author Benkarim OM
author_facet Benkarim OM
Hahner N
Piella G
Gratacos E
Gonzalez Ballester MA
Eixarch E
Sanroma G
author_role author
author2 Hahner N
Piella G
Gratacos E
Gonzalez Ballester MA
Eixarch E
Sanroma G
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv *Cortical folding
*Fetal brain
*Lasso
*MRI
*Statistical analysis
*Ventriculomegaly
topic *Cortical folding
*Fetal brain
*Lasso
*MRI
*Statistical analysis
*Ventriculomegaly
description Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain magnetic resonance images from 23 isolated non-severe ventriculomegaly (INSVM) fetuses and 25 healthy controls between 26 and 29 gestational weeks were used to identify INSVM-related cortical folding deviations from normative development. Since these alterations may reflect abnormal neurodevelopment, our working hypothesis is that markers of cortical folding can provide cues to improve the prediction of later neurodevelopmental problems in INSVM subjects. We analyzed the relationship of ventricular enlargement with cortical folding alterations in a regional basis using several curvature-based measures describing the folding of each cortical region. Statistical analysis (global and hemispheric) and sparse linear regression approaches were then used to find the cortical regions whose folding is associated with ventricular dilation. Results from both approaches were in great accordance, showing a significant cortical folding decrease in the insula, posterior part of the temporal lobe and occipital lobe. Moreover, compared to the global analysis, stronger ipsilateral associations of ventricular enlargement with reduced cortical folding were encountered by the hemispheric analysis. Our findings confirm and extend previous studies by identifying various cortical regions and emphasizing ipsilateral effects of ventricular enlargement in altered folding. This suggests that INSVM is an indicator of altered cortical development, and moreover, cortical regions with reduced folding constitute potential prognostic biomarkers to be used in follow-up studies to decipher the outcome of INSVM fetuses.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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format article
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dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13543
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13543
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv NeuroImage-Clinical
ISSN: 22131582
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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