Longitudinal assessment of abnormal cortical folding in fetuses and neonates with isolated non-severe ventriculomegaly
Purpose: The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention-deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some st...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:dnet:rdupf_______::0c141f2875d91a4c2905b066c0b91308 |
| Acceso en línea: | https://hdl.handle.net/10230/72818 http://dx.doi.org/10.1002/brb3.70255 |
| Access Level: | acceso abierto |
| Palabra clave: | Atlas-based segmentation Brain Fetal Longitudinal analysis Mixed-effects model MRI Neonatal Ventriculomegaly |
| Sumario: | Purpose: The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention-deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some studies have also shown a relationship between VM and cortical overgrowth, along with reduced cortical folding, both in fetuses and neonates. However, there is a lack of longitudinal studies that study this relationship from fetuses to neonates. Method: We used a longitudinal dataset of 30 subjects (15 healthy controls and 15 subjects diagnosed with isolated non-severe VM (INSVM)) with structural MRI acquired in and ex utero for each subject. We focused on the impact of fetal INSVM on cortical development from a longitudinal perspective, from the fetal to the neonatal stage. Particularly, we examined the relationship between ventricular enlargement and both volumetric features and a multifaceted set of cortical folding measures, including local gyrification, sulcal depth, curvature, and cortical thickness. Findings: Our results show significant effects of isolated non-severe VM (INSVM) compared to healthy controls, with reduced cortical thickness in specific brain regions such as the occipital, parietal, and frontal lobes. Conclusion: These findings align with existing literature, confirming the presence of alterations in cortical growth and folding in subjects with isolated non-severe VM (INSVM) from the fetal to neonatal stage compared to controls. |
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