Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting
Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index fo...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:292292 |
| Acceso en línea: | https://ddd.uab.cat/record/292292 https://dx.doi.org/urn:doi:10.3390/diagnostics11122236 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic liver disease Liver fibrosis Metabolic associated fatty liver disease (MAFLD) Screening Fibrosis 4 score |
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Assessing Liver Fibrosis Using the FIB4 Index in the Community SettingBlanco-Grau, Albert|||0000-0002-4213-3827Gabriel-Medina, Pablo|||0000-0003-3079-6364Rodriguez-Algarra, Francisco|||0000-0002-4134-2141Villena-Ortiz, Yolanda|||0000-0003-0925-0498Lopez-Martínez, RosaAugustin Recio, Salvador|||0000-0002-3515-9033Pons Delgado, Mònica|||0000-0002-0985-3320Cruz Carlos, Luz MariaRando-Segura, Ariadna|||0000-0003-4555-7286Enfedaque Montes, Belen|||0000-0002-2843-7250Riveiro Barciela, Mar|||0000-0001-9309-2052Casis-Saez, ErnestoFerrer Costa, Roser|||0000-0002-8925-3172Buti, Maria|||0000-0002-0732-3078Rodríguez Frías, Francisco|||0000-0002-9128-7013Chronic liver diseaseLiver fibrosisMetabolic associated fatty liver disease (MAFLD)ScreeningFibrosis 4 scoreLiver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 ≥ 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 ≥ 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a "red flag" for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292292https://dx.doi.org/urn:doi:10.3390/diagnostics11122236reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2922922026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| title |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| spellingShingle |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting Blanco-Grau, Albert|||0000-0002-4213-3827 Chronic liver disease Liver fibrosis Metabolic associated fatty liver disease (MAFLD) Screening Fibrosis 4 score |
| title_short |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| title_full |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| title_fullStr |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| title_full_unstemmed |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| title_sort |
Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting |
| dc.creator.none.fl_str_mv |
Blanco-Grau, Albert|||0000-0002-4213-3827 Gabriel-Medina, Pablo|||0000-0003-3079-6364 Rodriguez-Algarra, Francisco|||0000-0002-4134-2141 Villena-Ortiz, Yolanda|||0000-0003-0925-0498 Lopez-Martínez, Rosa Augustin Recio, Salvador|||0000-0002-3515-9033 Pons Delgado, Mònica|||0000-0002-0985-3320 Cruz Carlos, Luz Maria Rando-Segura, Ariadna|||0000-0003-4555-7286 Enfedaque Montes, Belen|||0000-0002-2843-7250 Riveiro Barciela, Mar|||0000-0001-9309-2052 Casis-Saez, Ernesto Ferrer Costa, Roser|||0000-0002-8925-3172 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author |
Blanco-Grau, Albert|||0000-0002-4213-3827 |
| author_facet |
Blanco-Grau, Albert|||0000-0002-4213-3827 Gabriel-Medina, Pablo|||0000-0003-3079-6364 Rodriguez-Algarra, Francisco|||0000-0002-4134-2141 Villena-Ortiz, Yolanda|||0000-0003-0925-0498 Lopez-Martínez, Rosa Augustin Recio, Salvador|||0000-0002-3515-9033 Pons Delgado, Mònica|||0000-0002-0985-3320 Cruz Carlos, Luz Maria Rando-Segura, Ariadna|||0000-0003-4555-7286 Enfedaque Montes, Belen|||0000-0002-2843-7250 Riveiro Barciela, Mar|||0000-0001-9309-2052 Casis-Saez, Ernesto Ferrer Costa, Roser|||0000-0002-8925-3172 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author_role |
author |
| author2 |
Gabriel-Medina, Pablo|||0000-0003-3079-6364 Rodriguez-Algarra, Francisco|||0000-0002-4134-2141 Villena-Ortiz, Yolanda|||0000-0003-0925-0498 Lopez-Martínez, Rosa Augustin Recio, Salvador|||0000-0002-3515-9033 Pons Delgado, Mònica|||0000-0002-0985-3320 Cruz Carlos, Luz Maria Rando-Segura, Ariadna|||0000-0003-4555-7286 Enfedaque Montes, Belen|||0000-0002-2843-7250 Riveiro Barciela, Mar|||0000-0001-9309-2052 Casis-Saez, Ernesto Ferrer Costa, Roser|||0000-0002-8925-3172 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Chronic liver disease Liver fibrosis Metabolic associated fatty liver disease (MAFLD) Screening Fibrosis 4 score |
| topic |
Chronic liver disease Liver fibrosis Metabolic associated fatty liver disease (MAFLD) Screening Fibrosis 4 score |
| description |
Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 ≥ 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 ≥ 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a "red flag" for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/292292 https://dx.doi.org/urn:doi:10.3390/diagnostics11122236 |
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https://ddd.uab.cat/record/292292 https://dx.doi.org/urn:doi:10.3390/diagnostics11122236 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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