Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting

Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index fo...

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Detalhes bibliográficos
Autores: Blanco-Grau, Albert|||0000-0002-4213-3827, Gabriel-Medina, Pablo|||0000-0003-3079-6364, Rodriguez-Algarra, Francisco|||0000-0002-4134-2141, Villena-Ortiz, Yolanda|||0000-0003-0925-0498, Lopez-Martínez, Rosa, Augustin Recio, Salvador|||0000-0002-3515-9033, Pons Delgado, Mònica|||0000-0002-0985-3320, Cruz Carlos, Luz Maria, Rando-Segura, Ariadna|||0000-0003-4555-7286, Enfedaque Montes, Belen|||0000-0002-2843-7250, Riveiro Barciela, Mar|||0000-0001-9309-2052, Casis-Saez, Ernesto, Ferrer Costa, Roser|||0000-0002-8925-3172, Buti, Maria|||0000-0002-0732-3078, Rodríguez Frías, Francisco|||0000-0002-9128-7013
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:292292
Acesso em linha:https://ddd.uab.cat/record/292292
https://dx.doi.org/urn:doi:10.3390/diagnostics11122236
Access Level:Acceso aberto
Palavra-chave:Chronic liver disease
Liver fibrosis
Metabolic associated fatty liver disease (MAFLD)
Screening
Fibrosis 4 score
Descrição
Resumo:Liver disease is frequently asymptomatic, challenging early identification in the primary care setting. The fibrosis 4 (FIB4) index is a liver fibrosis biomarker that is a potential alternative to liver biopsy for diagnosing and managing liver disease. This study aimed to calculate the FIB4 index for screening individuals at high risk of liver disease at the community level. This was a retrospective real-world study analyzing blood and serum test results from a central laboratory. The primary outcome was the number of individuals within each risk category for hepatic fibrosis: high risk (FIB4 ≥ 3.25) and low risk (FIB4 < 1.3). The analysis included samples from 31,753 patients, of which 18,102 were aged 40 to 75 years. In these patients, the FIB4 index had been explicitly requested in 1852 (10.2%) cases and estimated ad hoc in the rest. Of the 263 (1.5%) cases with FIB4 ≥ 3.25, the FIB4 index was requested in 46 (17.5%), and 52 (19.8%) showed evidence of liver fibrosis in their medical records, while the rest did not report any data regarding liver fibrosis. FIB4 is a simple score that can play a role as a "red flag" for early identification of patients at high risk of advanced liver fibrosis and their referral to specialized care.

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