Receptor-associated proteins and synaptic plasticity

Changes in synaptic strength are important for synaptic development and synaptic plasticity. Most directly responsible for these synaptic changes are alterations in synaptic receptor number and density. Although alterations in receptor density mediated by the insertion, lateral mobility, removal, an...

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Detalles Bibliográficos
Autores: Bruneau, Emile G., Esteban, José A., Akaaboune, Mohammed
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/33999
Acceso en línea:http://hdl.handle.net/10261/33999
Access Level:acceso abierto
Palabra clave:Scaffold
Dynamics
Rapsyn
Gephyrin
PSD-95
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spelling Receptor-associated proteins and synaptic plasticityBruneau, Emile G.Esteban, José A.Akaaboune, MohammedScaffoldDynamicsRapsynGephyrinPSD-95Changes in synaptic strength are important for synaptic development and synaptic plasticity. Most directly responsible for these synaptic changes are alterations in synaptic receptor number and density. Although alterations in receptor density mediated by the insertion, lateral mobility, removal, and recycling of receptors have been extensively studied, the dynamics and regulators of intracellular scaffolding proteins have only recently begun to be illuminated. In particular, a closer look at the receptor-associated proteins, which bind to receptors and are necessary for their synaptic localization and clustering, has revealed broader functions than previously thought and some rather unexpected thematic similarities. More than just “placeholders” or members of a passive protein “scaffold,” receptor-associated proteins in every synapse studied have been shown to provide a number of signaling roles. In addition, the most recent state-of-theart imaging has revealed that receptor-associated proteins are highly dynamic and are involved in regulating synaptic receptor density. Together, these results challenge the view that receptor-associated proteins are members of a static and stable scaffold and argue that their dynamic mobility may be essential for regulating activity-dependent changes in synaptic strength.—Bruneau, E. G., Esteban, J. A., Akaaboune, M. Receptorassociated proteins and synaptic plasticity. FASEB J. 23, 679–688 (2009)This work was supported by the U.S. National Institutes of Health (M.A.) and a National Research Service Award (G.B.), the National Science Foundation (M.A.), and the Muscular Dystrophy Association (M.A.).Peer reviewedFederation of American Societies for Experimental BiologyNational Institutes of Health (US)National Science Foundation (US)Muscular Dystrophy Association (US)201120112009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/33999reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1096/fj.08-107946info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/339992026-05-22T06:33:51Z
dc.title.none.fl_str_mv Receptor-associated proteins and synaptic plasticity
title Receptor-associated proteins and synaptic plasticity
spellingShingle Receptor-associated proteins and synaptic plasticity
Bruneau, Emile G.
Scaffold
Dynamics
Rapsyn
Gephyrin
PSD-95
title_short Receptor-associated proteins and synaptic plasticity
title_full Receptor-associated proteins and synaptic plasticity
title_fullStr Receptor-associated proteins and synaptic plasticity
title_full_unstemmed Receptor-associated proteins and synaptic plasticity
title_sort Receptor-associated proteins and synaptic plasticity
dc.creator.none.fl_str_mv Bruneau, Emile G.
Esteban, José A.
Akaaboune, Mohammed
author Bruneau, Emile G.
author_facet Bruneau, Emile G.
Esteban, José A.
Akaaboune, Mohammed
author_role author
author2 Esteban, José A.
Akaaboune, Mohammed
author2_role author
author
dc.contributor.none.fl_str_mv National Institutes of Health (US)
National Science Foundation (US)
Muscular Dystrophy Association (US)
dc.subject.none.fl_str_mv Scaffold
Dynamics
Rapsyn
Gephyrin
PSD-95
topic Scaffold
Dynamics
Rapsyn
Gephyrin
PSD-95
description Changes in synaptic strength are important for synaptic development and synaptic plasticity. Most directly responsible for these synaptic changes are alterations in synaptic receptor number and density. Although alterations in receptor density mediated by the insertion, lateral mobility, removal, and recycling of receptors have been extensively studied, the dynamics and regulators of intracellular scaffolding proteins have only recently begun to be illuminated. In particular, a closer look at the receptor-associated proteins, which bind to receptors and are necessary for their synaptic localization and clustering, has revealed broader functions than previously thought and some rather unexpected thematic similarities. More than just “placeholders” or members of a passive protein “scaffold,” receptor-associated proteins in every synapse studied have been shown to provide a number of signaling roles. In addition, the most recent state-of-theart imaging has revealed that receptor-associated proteins are highly dynamic and are involved in regulating synaptic receptor density. Together, these results challenge the view that receptor-associated proteins are members of a static and stable scaffold and argue that their dynamic mobility may be essential for regulating activity-dependent changes in synaptic strength.—Bruneau, E. G., Esteban, J. A., Akaaboune, M. Receptorassociated proteins and synaptic plasticity. FASEB J. 23, 679–688 (2009)
publishDate 2009
dc.date.none.fl_str_mv 2009
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/33999
url http://hdl.handle.net/10261/33999
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1096/fj.08-107946
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
publisher.none.fl_str_mv Federation of American Societies for Experimental Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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