New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes

The presence of type 2 diabetes acts as an accelerator of cognitive impairment (mild cognitive impairment and later dementia), with a significant impact on the management of the disease and its complications. Therefore, it is recommended to perform an annual evaluation of cognitive function in patie...

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Autores: Ciudin, Andreea|||0000-0001-5622-0203, Simó Canonge, Rafael|||0000-0003-0475-3096
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281750
Acceso en línea:https://ddd.uab.cat/record/281750
https://dx.doi.org/urn:doi:10.3389/fendo.2022.1024794
Access Level:acceso abierto
Palabra clave:Dementia
Type 2 diabetes
Mild cognitive impairment
Neuropsychological tests
Retinal microperimetry
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spelling New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetesCiudin, Andreea|||0000-0001-5622-0203Simó Canonge, Rafael|||0000-0003-0475-3096DementiaType 2 diabetesMild cognitive impairmentNeuropsychological testsRetinal microperimetryThe presence of type 2 diabetes acts as an accelerator of cognitive impairment (mild cognitive impairment and later dementia), with a significant impact on the management of the disease and its complications. Therefore, it is recommended to perform an annual evaluation of cognitive function in patients with diabetes older than 65 years. Current guidelines still recommend the use of the Minimental State Evaluation Test (MMSE) as screening test, but it has a modest sensitivity and specificity for identifying mild cognitive impairment. This represents an important gap because patients with mild cognitive impairment are at risk of progressing to dementia. The neurocognitive diagnosis is based on complex neuropsychological tests, which require specifically trained personnel and are time consuming, making its routine incorporation into daily clinical practice unfeasible. Therefore, at present there are no reliable biomarkers to identify patients with type 2 diabetes at increased risk of developing cognitive impairment. Since the brain and the retina have a common embryological origin, our Research Group, has worked over the last 10 years evaluating the usefulness of the retina as a "window" to the brain. We provided evidence that retinal microperimetry is a simple, feasible and useful tool for screening and monitoring cognitive function in patients with type 2 diabetes. We propose a review of actual tests recommended for screening of cognitive impairment as well as an update of new emerging methods, such as retinal microperimetry.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281750https://dx.doi.org/urn:doi:10.3389/fendo.2022.1024794reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2817502026-06-06T12:50:31Z
dc.title.none.fl_str_mv New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
title New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
spellingShingle New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
Ciudin, Andreea|||0000-0001-5622-0203
Dementia
Type 2 diabetes
Mild cognitive impairment
Neuropsychological tests
Retinal microperimetry
title_short New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
title_full New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
title_fullStr New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
title_full_unstemmed New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
title_sort New methods for the diagnosis and monitoring of cognitive function in patients with type 2 diabetes
dc.creator.none.fl_str_mv Ciudin, Andreea|||0000-0001-5622-0203
Simó Canonge, Rafael|||0000-0003-0475-3096
author Ciudin, Andreea|||0000-0001-5622-0203
author_facet Ciudin, Andreea|||0000-0001-5622-0203
Simó Canonge, Rafael|||0000-0003-0475-3096
author_role author
author2 Simó Canonge, Rafael|||0000-0003-0475-3096
author2_role author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Dementia
Type 2 diabetes
Mild cognitive impairment
Neuropsychological tests
Retinal microperimetry
topic Dementia
Type 2 diabetes
Mild cognitive impairment
Neuropsychological tests
Retinal microperimetry
description The presence of type 2 diabetes acts as an accelerator of cognitive impairment (mild cognitive impairment and later dementia), with a significant impact on the management of the disease and its complications. Therefore, it is recommended to perform an annual evaluation of cognitive function in patients with diabetes older than 65 years. Current guidelines still recommend the use of the Minimental State Evaluation Test (MMSE) as screening test, but it has a modest sensitivity and specificity for identifying mild cognitive impairment. This represents an important gap because patients with mild cognitive impairment are at risk of progressing to dementia. The neurocognitive diagnosis is based on complex neuropsychological tests, which require specifically trained personnel and are time consuming, making its routine incorporation into daily clinical practice unfeasible. Therefore, at present there are no reliable biomarkers to identify patients with type 2 diabetes at increased risk of developing cognitive impairment. Since the brain and the retina have a common embryological origin, our Research Group, has worked over the last 10 years evaluating the usefulness of the retina as a "window" to the brain. We provided evidence that retinal microperimetry is a simple, feasible and useful tool for screening and monitoring cognitive function in patients with type 2 diabetes. We propose a review of actual tests recommended for screening of cognitive impairment as well as an update of new emerging methods, such as retinal microperimetry.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281750
https://dx.doi.org/urn:doi:10.3389/fendo.2022.1024794
url https://ddd.uab.cat/record/281750
https://dx.doi.org/urn:doi:10.3389/fendo.2022.1024794
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
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dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
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