Retinal microperimetry

Background: There is clear association between type 2 diabetes (T2D) and cognitive decline. Retinal microperimetry is a useful tool for detecting cognitive impairment in T2D. Morbid obesity (MO) has been associated with cognitive impairment. Insulin resistance (IR) seems a major determinant, but the...

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Detalles Bibliográficos
Autores: Ciudin, Andreea|||0000-0001-5622-0203, Ortiz Zúñiga, Ángel Michael|||0000-0002-2982-5896, Fidilio, Enzamaria|||0000-0001-9358-9608, Romero, Diana, Sanchez, Marta, Comas Martínez, Marta|||0000-0002-1511-5447, González López, Óscar|||0000-0002-2597-9257, Vilallonga, Ramon|||0000-0001-9333-2765, Simó-Servat, Olga|||0000-0003-3483-652X, Hernández, Cristina|||0000-0002-3109-1721, Simó Canonge, Rafael|||0000-0003-0475-3096
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:216795
Acceso en línea:https://ddd.uab.cat/record/216795
https://dx.doi.org/urn:doi:10.3390/jcm8122181
Access Level:acceso abierto
Palabra clave:Morbid obesity
Cognitive impairment
Retinal microperimetry
Insulin resistance
Descripción
Sumario:Background: There is clear association between type 2 diabetes (T2D) and cognitive decline. Retinal microperimetry is a useful tool for detecting cognitive impairment in T2D. Morbid obesity (MO) has been associated with cognitive impairment. Insulin resistance (IR) seems a major determinant, but the data are unclear. The aim of this study was to evaluate the cognitive impairment in MO as well as the utility of retinal microperimetry in identifying these alterations. Methods: In total, 50 consecutive patients with MO were matched by age and gender with 30 healthy controls. All patients underwent cognitive evaluation (Montreal Cognitive Assessment Test-MoCA) and retinal microperimetry, using MAIA microperimeter 3rd generation. Retinal sensitivity and gaze fixation parameters were used for the evaluation of the analysis. Results: MO patients showed a significantly lower neurocognitive performance than the controls: MoCA score 24.94 ± 2.74 vs. 28.95 ± 1.05, p < 0.001. Cognitive function inversely correlated with the HOMA-IR (r = -0.402, p = 0.007). The AUROC for cognitive impairment using microperimetry was 0.807, CI 95% (0.592-0.947), p = 0.017. Conclusions: (1) Systemic insulin resistance is a major underlying mechanism accounting for the higher prevalence of cognitive impairment detected in young MO subjects. (2) Retinal microperimetry is a useful tool for identifying MO patients with cognitive impairment.

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