Selective copper-catalyzed cross-coupling of cyclopropyl and cyclobutyl 1,2-bis(boronates)
Herein we disclose an approach to perform the selective copper-catalyzed cross-coupling of 1,2-diborylcyclopropanes and cyclobutanes with different electrophiles. In the case of 1,2-diborylcyclopropanes, a simple alkoxide base was needed to promote the cross-coupling with either allyl halides, propa...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:biblosearchi::c3e18127ef19f71fd0ab92e9991e1b55 |
| Acceso en línea: | https://hdl.handle.net/10486/774400 https://dx.doi.org/10.1021/acs.orglett.6c01560 |
| Access Level: | acceso abierto |
| Palabra clave: | Química |
| Sumario: | Herein we disclose an approach to perform the selective copper-catalyzed cross-coupling of 1,2-diborylcyclopropanes and cyclobutanes with different electrophiles. In the case of 1,2-diborylcyclopropanes, a simple alkoxide base was needed to promote the cross-coupling with either allyl halides, propargyl halides, alkynyl halides, or electrophilic amines, which highlights the special reactivity of these diboron compounds. In the case of 1,2-diborylspirocyclobutanes, a site-selective activation of the less hindered boron was observed. Further functionalization of the remaining boryl moiety provides access to highly functionalized stereodefined cyclopropanes and spirocyclobutanes |
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