Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats
Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11 -somatostatin binding were measured in the frontoparietal...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1989 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/2979 |
| Acceso en línea: | http://hdl.handle.net/10017/2979 https://dx.doi.org/10.1016/0024-3205(89)90010-6 |
| Access Level: | acceso abierto |
| Palabra clave: | Cysteamine Rat Pentylenetetrazol Somatostatin Bioquímica Ciencia Biochemistry Science |
| Sumario: | Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11 -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: 1) SLI content was increased in the two areas; 2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; 3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, reversed the altered SLI levels and binding in these rats. |
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