Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome

Rossello, X. (Xavier)|||/items/fcf7bb00-eab8-480c-9f5c-db000045dc34; Ramallal, R. (Raul)|||/items/f956c97d-efb5-4df8-9115-b0a770fb2782; Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a; Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d; Alonso, A. (Alvaro)|||/items/8f47c33e-f330-43b7-bae0-75bd196ca13e; Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47; Fernández-Palomeque, C. (Carlos)|||/items/06fe9412-85c0-4fa8-8e0e-158767104d9b; Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7; Garrido-Uriarte, M. (María)|||/items/6785bff1-4024-4507-8d78-d827e11c0920; López-Rodríguez, L. (Luis)|||/items/903efa42-16e8-4e71-99fa-c5721c79a7a3; Díaz-Dorronsoro, I. (Inés)|||/items/eb812d3a-1796-4950-b894-c77b1b522c41; Zaldua-Irastorza, O. (Olatz)|||/items/1a5a8593-3297-498a-a97d-f4627ac5002c; Shah, A.J. (Amit J.)|||/items/1cea0c02-b7e4-40f4-aaad-6ed126284198; Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6; Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b; Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0

Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome

Aims: To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (Mets). Methods and results: Participants of the PREvención con DIeta MEDiterranea-Plus trial...

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Autores:	Rossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34, Ramallal, R. (Raul)\|\|\|/items/f956c97d-efb5-4df8-9115-b0a770fb2782, Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a, Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d, Alonso, A. (Alvaro)\|\|\|/items/8f47c33e-f330-43b7-bae0-75bd196ca13e, Tojal-Sierra, L. (Lucas)\|\|\|/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47, Fernández-Palomeque, C. (Carlos)\|\|\|/items/06fe9412-85c0-4fa8-8e0e-158767104d9b, Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Garrido-Uriarte, M. (María)\|\|\|/items/6785bff1-4024-4507-8d78-d827e11c0920, López-Rodríguez, L. (Luis)\|\|\|/items/903efa42-16e8-4e71-99fa-c5721c79a7a3, Díaz-Dorronsoro, I. (Inés)\|\|\|/items/eb812d3a-1796-4950-b894-c77b1b522c41, Zaldua-Irastorza, O. (Olatz)\|\|\|/items/1a5a8593-3297-498a-a97d-f4627ac5002c, Shah, A.J. (Amit J.)\|\|\|/items/1cea0c02-b7e4-40f4-aaad-6ed126284198, Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b, Toledo-Atucha, E. (Estefanía)\|\|\|/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
Tipo de recurso:	artículo
Fecha de publicación:	2024
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/69795
Acceso en línea:	https://hdl.handle.net/10171/69795
Access Level:	acceso abierto
Palabra clave:	Atrial fibrillation Intensive lifestyle intervention Mediterranean diet Metabolic syndrome Obesity

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spelling	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndromeRossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34Ramallal, R. (Raul)\|\|\|/items/f956c97d-efb5-4df8-9115-b0a770fb2782Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680aAlonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2dAlonso, A. (Alvaro)\|\|\|/items/8f47c33e-f330-43b7-bae0-75bd196ca13eTojal-Sierra, L. (Lucas)\|\|\|/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47Fernández-Palomeque, C. (Carlos)\|\|\|/items/06fe9412-85c0-4fa8-8e0e-158767104d9bMartínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Garrido-Uriarte, M. (María)\|\|\|/items/6785bff1-4024-4507-8d78-d827e11c0920López-Rodríguez, L. (Luis)\|\|\|/items/903efa42-16e8-4e71-99fa-c5721c79a7a3Díaz-Dorronsoro, I. (Inés)\|\|\|/items/eb812d3a-1796-4950-b894-c77b1b522c41Zaldua-Irastorza, O. (Olatz)\|\|\|/items/1a5a8593-3297-498a-a97d-f4627ac5002cShah, A.J. (Amit J.)\|\|\|/items/1cea0c02-b7e4-40f4-aaad-6ed126284198Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6bToledo-Atucha, E. (Estefanía)\|\|\|/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Atrial fibrillationIntensive lifestyle interventionMediterranean dietMetabolic syndromeObesityAims: To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (Mets). Methods and results: Participants of the PREvención con DIeta MEDiterranea-Plus trial (n = 6874) were randomized 1:1 to an ILI programme based on an energy-reduced Mediterranean diet, increased physical activity, and cognitive-behavioural weight management or to a control intervention of low-intensity dietary advice. A core echocardiography lab evaluated left atrial (LA) strain, function, and volumes in 534 participants at baseline, 3-year, and 5-year follow-ups. Mixed models were used to evaluate the effect of the ILI on LA structure and function. In the subsample, the baseline mean age was 65 years [standard deviation (SD) 5 years], and 40% of the participants were women. The mean weight change after 5 years was -3.9 kg (SD 5.3 kg) in the ILI group and -0.3 kg (SD 5.1 kg) in the control group. Over the 5-year period, both groups experienced a worsening of LA structure and function, with increases in LA volumes and stiffness index and decreases in LA longitudinal strain, LA function index, and LA emptying fraction over time. Changes in the ILI and control groups were not significantly different for any of the primary outcomes {LA emptying fraction: -0.95% [95% confidence interval (CI) -0.93, -0.98] in the control group, -0.97% [95% CI -0.94, -1.00] in the ILI group, Pbetween groups = 0.80; LA longitudinal strain: 0.82% [95% CI 0.79, 0.85] in the control group, 0.85% [95% CI 0.82, 0.89] in the ILI group, Pbetween groups = 0.24} or any of the secondary outcomes. Conclusion: In overweight or obese people with Mets, an ILI had no impact on the underlying structural and functional LA substrate measurements associated with AF risk.Dadun. Depósito Académico Digital Universidad de Navarra20242024-08-2920242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69795reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/697952026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
title	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
spellingShingle	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome Rossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34 Atrial fibrillation Intensive lifestyle intervention Mediterranean diet Metabolic syndrome Obesity
title_short	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
title_full	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
title_fullStr	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
title_full_unstemmed	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
title_sort	Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
dc.creator.none.fl_str_mv	Rossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34 Ramallal, R. (Raul)\|\|\|/items/f956c97d-efb5-4df8-9115-b0a770fb2782 Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Alonso, A. (Alvaro)\|\|\|/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Tojal-Sierra, L. (Lucas)\|\|\|/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fernández-Palomeque, C. (Carlos)\|\|\|/items/06fe9412-85c0-4fa8-8e0e-158767104d9b Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Garrido-Uriarte, M. (María)\|\|\|/items/6785bff1-4024-4507-8d78-d827e11c0920 López-Rodríguez, L. (Luis)\|\|\|/items/903efa42-16e8-4e71-99fa-c5721c79a7a3 Díaz-Dorronsoro, I. (Inés)\|\|\|/items/eb812d3a-1796-4950-b894-c77b1b522c41 Zaldua-Irastorza, O. (Olatz)\|\|\|/items/1a5a8593-3297-498a-a97d-f4627ac5002c Shah, A.J. (Amit J.)\|\|\|/items/1cea0c02-b7e4-40f4-aaad-6ed126284198 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)\|\|\|/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
author	Rossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34
author_facet	Rossello, X. (Xavier)\|\|\|/items/fcf7bb00-eab8-480c-9f5c-db000045dc34 Ramallal, R. (Raul)\|\|\|/items/f956c97d-efb5-4df8-9115-b0a770fb2782 Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Alonso, A. (Alvaro)\|\|\|/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Tojal-Sierra, L. (Lucas)\|\|\|/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fernández-Palomeque, C. (Carlos)\|\|\|/items/06fe9412-85c0-4fa8-8e0e-158767104d9b Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Garrido-Uriarte, M. (María)\|\|\|/items/6785bff1-4024-4507-8d78-d827e11c0920 López-Rodríguez, L. (Luis)\|\|\|/items/903efa42-16e8-4e71-99fa-c5721c79a7a3 Díaz-Dorronsoro, I. (Inés)\|\|\|/items/eb812d3a-1796-4950-b894-c77b1b522c41 Zaldua-Irastorza, O. (Olatz)\|\|\|/items/1a5a8593-3297-498a-a97d-f4627ac5002c Shah, A.J. (Amit J.)\|\|\|/items/1cea0c02-b7e4-40f4-aaad-6ed126284198 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)\|\|\|/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
author_role	author
author2	Ramallal, R. (Raul)\|\|\|/items/f956c97d-efb5-4df8-9115-b0a770fb2782 Romaguera, D. (Dora)\|\|\|/items/54bd463f-ee9f-4c7a-b33e-78633766680a Alonso-Gomez, A. (Ángel)\|\|\|/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Alonso, A. (Alvaro)\|\|\|/items/8f47c33e-f330-43b7-bae0-75bd196ca13e Tojal-Sierra, L. (Lucas)\|\|\|/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fernández-Palomeque, C. (Carlos)\|\|\|/items/06fe9412-85c0-4fa8-8e0e-158767104d9b Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Garrido-Uriarte, M. (María)\|\|\|/items/6785bff1-4024-4507-8d78-d827e11c0920 López-Rodríguez, L. (Luis)\|\|\|/items/903efa42-16e8-4e71-99fa-c5721c79a7a3 Díaz-Dorronsoro, I. (Inés)\|\|\|/items/eb812d3a-1796-4950-b894-c77b1b522c41 Zaldua-Irastorza, O. (Olatz)\|\|\|/items/1a5a8593-3297-498a-a97d-f4627ac5002c Shah, A.J. (Amit J.)\|\|\|/items/1cea0c02-b7e4-40f4-aaad-6ed126284198 Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Toledo-Atucha, E. (Estefanía)\|\|\|/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
author2_role	author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Atrial fibrillation Intensive lifestyle intervention Mediterranean diet Metabolic syndrome Obesity
topic	Atrial fibrillation Intensive lifestyle intervention Mediterranean diet Metabolic syndrome Obesity
description	Aims: To evaluate the effect of an intensive lifestyle intervention (ILI) on the structural and functional cardiac substrate of atrial fibrillation (AF) in overweight or obese people with metabolic syndrome (Mets). Methods and results: Participants of the PREvención con DIeta MEDiterranea-Plus trial (n = 6874) were randomized 1:1 to an ILI programme based on an energy-reduced Mediterranean diet, increased physical activity, and cognitive-behavioural weight management or to a control intervention of low-intensity dietary advice. A core echocardiography lab evaluated left atrial (LA) strain, function, and volumes in 534 participants at baseline, 3-year, and 5-year follow-ups. Mixed models were used to evaluate the effect of the ILI on LA structure and function. In the subsample, the baseline mean age was 65 years [standard deviation (SD) 5 years], and 40% of the participants were women. The mean weight change after 5 years was -3.9 kg (SD 5.3 kg) in the ILI group and -0.3 kg (SD 5.1 kg) in the control group. Over the 5-year period, both groups experienced a worsening of LA structure and function, with increases in LA volumes and stiffness index and decreases in LA longitudinal strain, LA function index, and LA emptying fraction over time. Changes in the ILI and control groups were not significantly different for any of the primary outcomes {LA emptying fraction: -0.95% [95% confidence interval (CI) -0.93, -0.98] in the control group, -0.97% [95% CI -0.94, -1.00] in the ILI group, Pbetween groups = 0.80; LA longitudinal strain: 0.82% [95% CI 0.79, 0.85] in the control group, 0.85% [95% CI 0.82, 0.89] in the ILI group, Pbetween groups = 0.24} or any of the secondary outcomes. Conclusion: In overweight or obese people with Mets, an ILI had no impact on the underlying structural and functional LA substrate measurements associated with AF risk.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024-08-29 2024 2024-01-01 2024 2024-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/69795
url	https://hdl.handle.net/10171/69795
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
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dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
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Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome

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