Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a crit...

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Detalles Bibliográficos
Autores: Rodríguez García, Marta, Climent Vidal, Núria, Oliva, Harold, Casanova Güell, Víctor, Franco Fernández, Rafael, León García, Agathe, Gatell, José M., García, Felipe, Gallart, Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/42863
Acceso en línea:https://hdl.handle.net/2445/42863
Access Level:acceso abierto
Palabra clave:VIH (Virus)
Immunologia
HIV (Viruses)
Immunology
Descripción
Sumario:Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce α-defensins1-3 and that α-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of α-defensins1-3 production by DC on disease progression.

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