A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study

BACKGROUND: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain....

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Autores: Perez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758, Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca, Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57, Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb, Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e, Lacunza, C.I. (Clara I.)|||/items/77525627-2509-46ed-98c6-24d6c146c28a, Lahortiga-Ramos, F. (Francisca)|||/items/a20ad65f-6a0e-4d0b-bed4-c7d2c2fb8c57, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/35845
Acceso en línea:https://hdl.handle.net/10171/35845
Access Level:acceso abierto
Palabra clave:Metabolic syndrome
Depression
Inflammation
Leptin
Hypocaloric diet
Adiposity
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spelling A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal studyPerez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2acaLopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fbNavas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20eLacunza, C.I. (Clara I.)|||/items/77525627-2509-46ed-98c6-24d6c146c28aLahortiga-Ramos, F. (Francisca)|||/items/a20ad65f-6a0e-4d0b-bed4-c7d2c2fb8c57Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239Metabolic syndromeDepressionInflammationLeptinHypocaloric dietAdiposityBACKGROUND: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors. METHODS: Sixty subjects (Age:50 +/- 1 y; BMI:36.1 +/- 0.6 kg/m2) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated. RESULTS: Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 +/- 0.8 vs RESMENA group -3.2 +/- 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95%CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95%CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95%CI = 1.8-6.8), CRP (-42.8%; 95%CI = 0.6-3.0) and insulin (-37.7%; 95%CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95%CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95%CI = 0.04-0.28) and CRP (B = 0.24, 95%CI = 0.01-0.46) concentrations. CONCLUSIONS: The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS.BioMed CentralDadun. Depósito Académico Digital Universidad de Navarra20142014-05-1220142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/35845reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/358452026-06-21T12:47:57Z
dc.title.none.fl_str_mv A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
title A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
spellingShingle A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
Perez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758
Metabolic syndrome
Depression
Inflammation
Leptin
Hypocaloric diet
Adiposity
title_short A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
title_full A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
title_fullStr A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
title_full_unstemmed A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
title_sort A decline in inflammation is associated with less depressive symptoms after a dietary intervention in metabolic syndrome patients: a longitudinal study
dc.creator.none.fl_str_mv Perez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758
Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb
Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e
Lacunza, C.I. (Clara I.)|||/items/77525627-2509-46ed-98c6-24d6c146c28a
Lahortiga-Ramos, F. (Francisca)|||/items/a20ad65f-6a0e-4d0b-bed4-c7d2c2fb8c57
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
author Perez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758
author_facet Perez-Cornago, A. (Aurora)|||/items/af5a31a9-f005-4ef4-9673-bff580cd1758
Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb
Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e
Lacunza, C.I. (Clara I.)|||/items/77525627-2509-46ed-98c6-24d6c146c28a
Lahortiga-Ramos, F. (Francisca)|||/items/a20ad65f-6a0e-4d0b-bed4-c7d2c2fb8c57
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
author_role author
author2 Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57
Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb
Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e
Lacunza, C.I. (Clara I.)|||/items/77525627-2509-46ed-98c6-24d6c146c28a
Lahortiga-Ramos, F. (Francisca)|||/items/a20ad65f-6a0e-4d0b-bed4-c7d2c2fb8c57
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Metabolic syndrome
Depression
Inflammation
Leptin
Hypocaloric diet
Adiposity
topic Metabolic syndrome
Depression
Inflammation
Leptin
Hypocaloric diet
Adiposity
description BACKGROUND: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors. METHODS: Sixty subjects (Age:50 +/- 1 y; BMI:36.1 +/- 0.6 kg/m2) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated. RESULTS: Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 +/- 0.8 vs RESMENA group -3.2 +/- 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95%CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95%CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95%CI = 1.8-6.8), CRP (-42.8%; 95%CI = 0.6-3.0) and insulin (-37.7%; 95%CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95%CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95%CI = 0.04-0.28) and CRP (B = 0.24, 95%CI = 0.01-0.46) concentrations. CONCLUSIONS: The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-05-12
2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/35845
url https://hdl.handle.net/10171/35845
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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