Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients

Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of Metabolic Syndrome (MetS) patients following a hypocaloric diet. Design Ninety-three Caucasian adults (52 men/...

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Detalles Bibliográficos
Autores: Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Casanueva, F.F. (Felipe F.)|||/items/6e2fea43-337d-4897-84ed-7feead87f59f, Pardo, M. (M.)|||/items/e8a7e482-114c-43c8-84a7-f3893f07a0a2, Crujeiras, A.B. (Ana B.)|||/items/63af043e-dbbb-4859-a9a7-11317aadb9de, Lopez-Legarrea, P. (Patricia)|||/items/4783fc8c-2687-4fc4-84df-57e7662a8c57, Iglesia, R. (Rocío) de la|||/items/8f8a7cd3-8633-455e-a533-a4ce490c2aca
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/35862
Acceso en línea:https://hdl.handle.net/10171/35862
Access Level:acceso abierto
Palabra clave:Apolipoprotein B
Cholesterol
Atherogenic
Hypocaloric
RESMENA
Descripción
Sumario:Objective A recently discovered myokine, irisin, may have an important role in energy metabolism. This study aimed to evaluate the relationship between this hormone and the lipid profile of Metabolic Syndrome (MetS) patients following a hypocaloric diet. Design Ninety-three Caucasian adults (52 men/41 women) diagnosed with MetS followed an 8-week-long energy restricted programme (-30% of the energy requirements). Anthropometric measurements, biochemical markers and plasma irisin levels were analysed before and after the nutritional intervention. Results Global plasma irisin levels were significantly reduced at the end of the study (-72•0 ± 100•9 ng/mL, p < 0•001) accompanying the weight loss (-6•9%). The depletion of irisin significantly correlated with changes in some atherogenic-related variables: total cholesterol (B = 0•106, p = 0•018), total cholesterol/high density lipoprotein-cholesterol ratio (B = 0•002, p = 0•036), low density lipoprotein-cholesterol (B = 0•085, p = 0•037) and apolipoprotein B (B = 0•052, p = 0•002), independently of changes in body weight. Conclusions An association between the reduction of plasma irisin levels and the depletion of important lipid metabolism biomarkers was observed in patients with MetS undergoing an energy restricted programme.

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