Cyclins and CDKs in the regulation of meiosis-specific events

Molecular Architecture and Dynamics of Meiotic Chromosomes.

Detalles Bibliográficos
Autores: Palacios-Blanco, Inés, Martín-Castellanos, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/287079
Acceso en línea:http://hdl.handle.net/10261/287079
https://api.elsevier.com/content/abstract/scopus_id/85143895012
Access Level:acceso abierto
Palabra clave:Meiosis
Prophase
Cyclins
CDKs
Nuclear architecture
Recombination
Synpasis
Substrates
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spelling Cyclins and CDKs in the regulation of meiosis-specific eventsPalacios-Blanco, InésMartín-Castellanos, CristinaMeiosisProphaseCyclinsCDKsNuclear architectureRecombinationSynpasisSubstratesMolecular Architecture and Dynamics of Meiotic Chromosomes.How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events. During cell cycle progression, the cellular level of CDK (Cyclin-Dependent Kinase) activity temporally orders the different cell cycle phases, ensuring that DNA replication occurs prior to segregation into two daughter cells. CDK activity requires the binding of a regulatory subunit (cyclin) to the core kinase, and both CDKs and cyclins are well conserved throughout evolution from yeast to humans. As key regulators, they coordinate cell cycle progression with metabolism, DNA damage, and cell differentiation. In meiosis, the special cell division that ensures the transmission of genetic information from one generation to the next, cyclins and CDKs have acquired novel functions to coordinate meiosis-specific events such as chromosome architecture, recombination, and synapsis. Interestingly, meiosis-specific cyclins and CDKs are common in evolution, some cyclins seem to have evolved to acquire CDK-independent functions, and even some CDKs associate with a non-cyclin partner. We will review the functions of these key regulators in meiosis where variation has specially flourished.Work in our laboratory is funded by grants from the MCIN/AEI/10.13039/501100011033/& FEDER “Una manera de hacer Europa,” Grant Number FEDER-PGC2018-101908-B-I00; and Junta de Castilla y León, Grant Number CSI259P20 which is co-funded by FEDER program. Furthermore, our institute (IBFG) is funded by the Program “Escalera de Excelencia” of the Junta de Castilla y León Ref. CLU-2017-03 co-funded by the P.O. FEDER of Castilla y León 14-20; and the Internationalization Project “CL-EI-2021-08 - IBFG Unit of Excellence” of the CSIC, funded by the Junta de Castilla y León and co-financed by the European Union (ERDF “Europe drives our growth”).Peer reviewedFrontiers MediaMinisterio de Ciencia e Innovación (España)Junta de Castilla y LeónAgencia Estatal de Investigación (España)European CommissionMartín-Castellanos, Cristina [0000-0002-1303-2517]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/287079https://api.elsevier.com/content/abstract/scopus_id/85143895012reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-101908-B-I00https://doi.org/10.3389/fcell.2022.1069064Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2870792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cyclins and CDKs in the regulation of meiosis-specific events
title Cyclins and CDKs in the regulation of meiosis-specific events
spellingShingle Cyclins and CDKs in the regulation of meiosis-specific events
Palacios-Blanco, Inés
Meiosis
Prophase
Cyclins
CDKs
Nuclear architecture
Recombination
Synpasis
Substrates
title_short Cyclins and CDKs in the regulation of meiosis-specific events
title_full Cyclins and CDKs in the regulation of meiosis-specific events
title_fullStr Cyclins and CDKs in the regulation of meiosis-specific events
title_full_unstemmed Cyclins and CDKs in the regulation of meiosis-specific events
title_sort Cyclins and CDKs in the regulation of meiosis-specific events
dc.creator.none.fl_str_mv Palacios-Blanco, Inés
Martín-Castellanos, Cristina
author Palacios-Blanco, Inés
author_facet Palacios-Blanco, Inés
Martín-Castellanos, Cristina
author_role author
author2 Martín-Castellanos, Cristina
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Junta de Castilla y León
Agencia Estatal de Investigación (España)
European Commission
Martín-Castellanos, Cristina [0000-0002-1303-2517]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Meiosis
Prophase
Cyclins
CDKs
Nuclear architecture
Recombination
Synpasis
Substrates
topic Meiosis
Prophase
Cyclins
CDKs
Nuclear architecture
Recombination
Synpasis
Substrates
description Molecular Architecture and Dynamics of Meiotic Chromosomes.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/287079
https://api.elsevier.com/content/abstract/scopus_id/85143895012
url http://hdl.handle.net/10261/287079
https://api.elsevier.com/content/abstract/scopus_id/85143895012
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-101908-B-I00
https://doi.org/10.3389/fcell.2022.1069064
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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