New insights into Cdk2 regulation during meiosis

Cyclin dependent kinases (CDKs) are proline-directed serine/threonine kinases that play a central role in regulating cell cycle progression. Since the activity of CDKs depends on the binding of regulatory subunit named cyclins, the analysis of the CDK functions that have been studied so far has usua...

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Detalles Bibliográficos
Autores: Isoda, Michitaka, Mikolcevic, Petra, Nebreda, Àngel R.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/105629
Acceso en línea:https://hdl.handle.net/2445/105629
Access Level:acceso abierto
Palabra clave:Meiosi
Ciclines
Meiosis
Cyclins
Descripción
Sumario:Cyclin dependent kinases (CDKs) are proline-directed serine/threonine kinases that play a central role in regulating cell cycle progression. Since the activity of CDKs depends on the binding of regulatory subunit named cyclins, the analysis of the CDK functions that have been studied so far has usually gone in parallel to the study of cyclins. However, the proteins referred to as RINGO or Speedy, which have no amino acid sequence homology to cyclins, have been found to function as atypical CDK activators.