Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model

Crimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection a...

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Autores: Baz-Flores, Sara, Herraiz, Cesar, Peralbo-Moreno, Alfonso, Barral, Marta, Arnal, Maria C.|||0000-0002-6770-3400, Balseiro, Ana|||0000-0002-5121-7264, Cano-Terriza, David|||0000-0001-5657-2567, Castro-Scholten, Sabrina|||0000-0001-8761-5945, Cevidanes, Aitor, Conde-Lizarralde, Alazne, Cuadrado Matías, Raúl|||0000-0002-4827-6095, Escribano, Fernando, Fernández de Luco, Daniel|||0000-0003-3289-4267, Fidalgo, Luis Eusebio, Hermoso-de Mendoza, Javier, Fandos, Paulino|||0000-0002-9607-8931, Gómez Guillamón, Félix, Granados Torres, José Enrique|||0000-0002-9787-9896, Jiménez-Martín, Débora, López Olvera, Jorge R.|||0000-0002-2999-3451, Martín, Inés, Martínez, Remigio, Mentaberre García, Gregorio|||0000-0001-9542-7514, García Bocanegra, Ignacio|||0000-0003-3388-2604, Ruiz-Fons, Francisco
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:306743
Acceso en línea:https://ddd.uab.cat/record/306743
https://dx.doi.org/urn:doi:10.1016/j.ttbdis.2023.102281
Access Level:acceso abierto
Palabra clave:Hyalomma
Orthonairovirus
Risk map
Serosurvey
Tick
Zoonosis
SDG 3 - Good Health and Well-being
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repository_id_str
spelling Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a modelBaz-Flores, SaraHerraiz, CesarPeralbo-Moreno, AlfonsoBarral, MartaArnal, Maria C.|||0000-0002-6770-3400Balseiro, Ana|||0000-0002-5121-7264Cano-Terriza, David|||0000-0001-5657-2567Castro-Scholten, Sabrina|||0000-0001-8761-5945Cevidanes, AitorConde-Lizarralde, AlazneCuadrado Matías, Raúl|||0000-0002-4827-6095Escribano, FernandoFernández de Luco, Daniel|||0000-0003-3289-4267Fidalgo, Luis EusebioHermoso-de Mendoza, JavierFandos, Paulino|||0000-0002-9607-8931Gómez Guillamón, FélixGranados Torres, José Enrique|||0000-0002-9787-9896Jiménez-Martín, DéboraLópez Olvera, Jorge R.|||0000-0002-2999-3451Martín, InésMartínez, RemigioMentaberre García, Gregorio|||0000-0001-9542-7514García Bocanegra, Ignacio|||0000-0003-3388-2604Ruiz-Fons, FranciscoHyalommaOrthonairovirusRisk mapSerosurveyTickZoonosisSDG 3 - Good Health and Well-beingCrimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection are mainly manifested in humans, but the virus replicates in several animal species. Understanding the determinants of CCHFV exposure risk from animal models is essential to predicting high-risk exposure hotspots for public health action. With this objective in mind, we designed a cross-sectional study of Eurasian wild boar (Sus scrofa) in Spain and Portugal. The study analysed 5,291 sera collected between 2006 and 2022 from 90 wild boar populations with a specific double-antigen ELISA to estimate CCHFV serum prevalence and identify the main determinants of exposure probability. To do so, we statistically modelled exposure risk with host- and environment-related predictors and spatially projected it at a 10 × 10 km square resolution at the scale of the Iberian Peninsula to map foci of infection risk. Fifty-seven (63.3 %) of the 90 populations had at least one seropositive animal, with seroprevalence ranging from 0.0 to 88.2 %. Anti-CCHFV antibodies were found in 1,026 of 5,291 wild boar (19.4 %; 95 % confidence interval: 18.3-20.5 %), with highest exposure rates in southwestern Iberia. The most relevant predictors of virus exposure risk were wild boar abundance, local rainfall regime, shrub cover, winter air temperature and soil temperature variation. The spatial projection of the best-fit model identified high-risk foci as occurring in most of western and southwestern Iberia and identified recently confirmed risk foci in eastern Spain. The results of the study demonstrate that serological surveys of CCHFV vector hosts are a powerful, robust and highly informative tool for public health authorities to take action to prevent human cases of CCHF in enzootic and emergency settings. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/306743https://dx.doi.org/urn:doi:10.1016/j.ttbdis.2023.102281reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 10.13039/501100011033Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-89866-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3067432026-06-06T12:50:31Z
dc.title.none.fl_str_mv Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
title Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
spellingShingle Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
Baz-Flores, Sara
Hyalomma
Orthonairovirus
Risk map
Serosurvey
Tick
Zoonosis
SDG 3 - Good Health and Well-being
title_short Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
title_full Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
title_fullStr Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
title_full_unstemmed Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
title_sort Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
dc.creator.none.fl_str_mv Baz-Flores, Sara
Herraiz, Cesar
Peralbo-Moreno, Alfonso
Barral, Marta
Arnal, Maria C.|||0000-0002-6770-3400
Balseiro, Ana|||0000-0002-5121-7264
Cano-Terriza, David|||0000-0001-5657-2567
Castro-Scholten, Sabrina|||0000-0001-8761-5945
Cevidanes, Aitor
Conde-Lizarralde, Alazne
Cuadrado Matías, Raúl|||0000-0002-4827-6095
Escribano, Fernando
Fernández de Luco, Daniel|||0000-0003-3289-4267
Fidalgo, Luis Eusebio
Hermoso-de Mendoza, Javier
Fandos, Paulino|||0000-0002-9607-8931
Gómez Guillamón, Félix
Granados Torres, José Enrique|||0000-0002-9787-9896
Jiménez-Martín, Débora
López Olvera, Jorge R.|||0000-0002-2999-3451
Martín, Inés
Martínez, Remigio
Mentaberre García, Gregorio|||0000-0001-9542-7514
García Bocanegra, Ignacio|||0000-0003-3388-2604
Ruiz-Fons, Francisco
author Baz-Flores, Sara
author_facet Baz-Flores, Sara
Herraiz, Cesar
Peralbo-Moreno, Alfonso
Barral, Marta
Arnal, Maria C.|||0000-0002-6770-3400
Balseiro, Ana|||0000-0002-5121-7264
Cano-Terriza, David|||0000-0001-5657-2567
Castro-Scholten, Sabrina|||0000-0001-8761-5945
Cevidanes, Aitor
Conde-Lizarralde, Alazne
Cuadrado Matías, Raúl|||0000-0002-4827-6095
Escribano, Fernando
Fernández de Luco, Daniel|||0000-0003-3289-4267
Fidalgo, Luis Eusebio
Hermoso-de Mendoza, Javier
Fandos, Paulino|||0000-0002-9607-8931
Gómez Guillamón, Félix
Granados Torres, José Enrique|||0000-0002-9787-9896
Jiménez-Martín, Débora
López Olvera, Jorge R.|||0000-0002-2999-3451
Martín, Inés
Martínez, Remigio
Mentaberre García, Gregorio|||0000-0001-9542-7514
García Bocanegra, Ignacio|||0000-0003-3388-2604
Ruiz-Fons, Francisco
author_role author
author2 Herraiz, Cesar
Peralbo-Moreno, Alfonso
Barral, Marta
Arnal, Maria C.|||0000-0002-6770-3400
Balseiro, Ana|||0000-0002-5121-7264
Cano-Terriza, David|||0000-0001-5657-2567
Castro-Scholten, Sabrina|||0000-0001-8761-5945
Cevidanes, Aitor
Conde-Lizarralde, Alazne
Cuadrado Matías, Raúl|||0000-0002-4827-6095
Escribano, Fernando
Fernández de Luco, Daniel|||0000-0003-3289-4267
Fidalgo, Luis Eusebio
Hermoso-de Mendoza, Javier
Fandos, Paulino|||0000-0002-9607-8931
Gómez Guillamón, Félix
Granados Torres, José Enrique|||0000-0002-9787-9896
Jiménez-Martín, Débora
López Olvera, Jorge R.|||0000-0002-2999-3451
Martín, Inés
Martínez, Remigio
Mentaberre García, Gregorio|||0000-0001-9542-7514
García Bocanegra, Ignacio|||0000-0003-3388-2604
Ruiz-Fons, Francisco
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hyalomma
Orthonairovirus
Risk map
Serosurvey
Tick
Zoonosis
SDG 3 - Good Health and Well-being
topic Hyalomma
Orthonairovirus
Risk map
Serosurvey
Tick
Zoonosis
SDG 3 - Good Health and Well-being
description Crimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection are mainly manifested in humans, but the virus replicates in several animal species. Understanding the determinants of CCHFV exposure risk from animal models is essential to predicting high-risk exposure hotspots for public health action. With this objective in mind, we designed a cross-sectional study of Eurasian wild boar (Sus scrofa) in Spain and Portugal. The study analysed 5,291 sera collected between 2006 and 2022 from 90 wild boar populations with a specific double-antigen ELISA to estimate CCHFV serum prevalence and identify the main determinants of exposure probability. To do so, we statistically modelled exposure risk with host- and environment-related predictors and spatially projected it at a 10 × 10 km square resolution at the scale of the Iberian Peninsula to map foci of infection risk. Fifty-seven (63.3 %) of the 90 populations had at least one seropositive animal, with seroprevalence ranging from 0.0 to 88.2 %. Anti-CCHFV antibodies were found in 1,026 of 5,291 wild boar (19.4 %; 95 % confidence interval: 18.3-20.5 %), with highest exposure rates in southwestern Iberia. The most relevant predictors of virus exposure risk were wild boar abundance, local rainfall regime, shrub cover, winter air temperature and soil temperature variation. The spatial projection of the best-fit model identified high-risk foci as occurring in most of western and southwestern Iberia and identified recently confirmed risk foci in eastern Spain. The results of the study demonstrate that serological surveys of CCHFV vector hosts are a powerful, robust and highly informative tool for public health authorities to take action to prevent human cases of CCHF in enzootic and emergency settings.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/306743
https://dx.doi.org/urn:doi:10.1016/j.ttbdis.2023.102281
url https://ddd.uab.cat/record/306743
https://dx.doi.org/urn:doi:10.1016/j.ttbdis.2023.102281
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 10.13039/501100011033
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-89866-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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