Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model

[EN]Crimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infecti...

Descripción completa

Detalles Bibliográficos
Autores: Baz Flores, Sara, Herraiz, Cesar, Peralbo Moreno, Alfonso, Barral, Marta, Arnal, María Cruz, Balseiro Morales, Ana María, Cano Terriza, David, Castro Scholten, Sabrina, Cevidanes, Aitor, Conde Lizarralde, Alazne, Cuadrado Matías, Raúl, Escribano, Fernando, Fernández de Luco, Daniel, Fidalgo, Luis Eusebio, Hermoso de Mendoza, Javier, Fandos, Paulino, Gómez Guillamón, Félix, Granados, José Enrique, Jiménez Martín, Débora, López Olvera, Jorge Ramón, Martín, Inés, Martínez, Remigio, Mentaberre, Gregorio, García Bocanegra, Ignacio, Ruiz Fons, José Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de León
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/26149
Acceso en línea:https://www.sciencedirect.com/science/article/pii/S1877959X23001620?via%3Dihub
https://hdl.handle.net/10612/26149
Access Level:acceso abierto
Palabra clave:Sanidad animal
Veterinaria
Hyalomma
Orthonairovirus
Risk map
Serosurvey
Tick
Zoonosis
3202 Epidemiología
3109 Ciencias Veterinarias
3212 Salud Publica
3210 Medicina Preventiva
Descripción
Sumario:[EN]Crimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection are mainly manifested in humans, but the virus replicates in several animal species. Understanding the determinants of CCHFV exposure risk from animal models is essential to predicting high-risk exposure hotspots for public health action. With this objective in mind, we designed a cross-sectional study of Eurasian wild boar (Sus scrofa) in Spain and Portugal. The study analysed 5,291 sera collected between 2006 and 2022 from 90 wild boar populations with a specific double-antigen ELISA to estimate CCHFV serum prevalence and identify the main determinants of exposure probability. To do so, we statistically modelled exposure risk with host- and environment-related predictors and spatially projected it at a 10 × 10 km square resolution at the scale of the Iberian Peninsula to map foci of infection risk. Fifty-seven (63.3 %) of the 90 populations had at least one seropositive animal, with seroprevalence ranging from 0.0 to 88.2 %. Anti-CCHFV antibodies were found in 1,026 of 5,291 wild boar (19.4 %; 95 % confidence interval: 18.3–20.5 %), with highest exposure rates in southwestern Iberia. The most relevant predictors of virus exposure risk were wild boar abundance, local rainfall regime, shrub cover, winter air temperature and soil temperature variation. The spatial projection of the best-fit model identified high-risk foci as occurring in most of western and southwestern Iberia and identified recently confirmed risk foci in eastern Spain. The results of the study demonstrate that serological surveys of CCHFV vector hosts are a powerful, robust and highly informative tool for public health authorities to take action to prevent human cases of CCHF in enzootic and emergency settings.

Similares en LA Referencia