Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study

Background: High blood pressure and poor cardiorespiratory ftness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifable risk factors are associated with dementia risk. Methods: In this prospective cohort study, we used data...

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Authors: Lerfald, Maren, Allore, Heather, Nilsen, Tom I. L., Eldholm, Rannveig S., Martínez Velilla, Nicolás, Selbæk, Geir, Ernstsen, Linda
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/52105
Online Access:https://hdl.handle.net/2454/52105
Access Level:Open access
Keyword:Cardiovascular
Cognition
Prevention
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spelling Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT studyLerfald, MarenAllore, HeatherNilsen, Tom I. L.Eldholm, Rannveig S.Martínez Velilla, NicolásSelbæk, GeirErnstsen, LindaCardiovascularCognitionPreventionBackground: High blood pressure and poor cardiorespiratory ftness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifable risk factors are associated with dementia risk. Methods: In this prospective cohort study, we used data from the population-based Trøndelag Health (HUNT) Study, Norway. We applied groupbased multidimensional trajectory modeling to identify age-specifc multidimensional trajectories of SBP, DBP, and estimated cardiorespiratory ftness across 3 surveys (HUNT1, 1984–1986 to HUNT3, 2006–2008). Dementia was diagnosed in the HUNT4 70+ substudy in 2017–2019. We used multivariate logistic regression to estimate odds ratios (ORs) and risk differences (RDs) of dementia. Results: In total, 7 594 participants (54.9% women) were included, with a mean age of 44.7 (SD 6.3) years at HUNT1. Dementia was diagnosed in 1 062 (14.0%) participants. We identifed 2 multidimensional trajectories throughout adulthood within 3 age groups: one with higher systolic blood pressure (SBP) and diastolic blood pressure (DBP), and lower estimated cardiorespiratory ftness (the poorer group), and one with lower SBP and DBP, and higher cardiorespiratory ftness (the better group). After adjustment for sex, apolipoprotein E ε4 status, education, marital status, and diabetes, the better group had consistently lower risk of dementia in all age groups with the lowest OR in the middle-aged group of 0.63 (95% confdence intervals [95% CI]: 0.51, 0.78) with corresponding RD of −0.07 (95% CI: −0.10, −0.04). Conclusions: Having a benefcial multidimensional trajectory of SBP, DBP, and cardiorespiratory ftness in adulthood was associated with reduced dementia risk. Aiming for optimal SBP, DBP, and estimated cardiorespiratory ftness throughout adulthood may reduce dementia risk.This work was supported by the Liaison Committee for education, research, and innovation in Central Norway (grant number 2022-30545). The source of funding had no role in the planning, design, analysis of data, interpretation of the results, or writing of the manuscript. The genotyping in Trøndelag Health Study (HUNT) was financed by the National Institutes of Health; University of Michigan; the Research Council of Norway; the Liaison Committee for Education, Research, and Innovation in Central Norway; and the Joint Research Committee between St. Olavs Hospital and the Faculty of Medicine and Health Sciences, NTNU. H.A. reports grants from NIH/NIA ID#: U54AG063546, grants from NIH/NIA ID#: P30AG066508, grants from NIH/NIA ID#: R61 AG069822, grants from NIH/NIA ID#: RF1AG058545, grants from NIH/NIA ID#: P30AG021342, grants from NIH/NIAID ID#: U19AI089992, from NIH/NCATS ID#: UL1TR001863, grants from NIH/NIAID ID#: R01AI142624, during the conduct of the study.Oxford University PressCiencias de la SaludOsasun Zientziak2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/mswordhttps://hdl.handle.net/2454/52105reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licensehttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/521052026-06-17T12:41:47Z
dc.title.none.fl_str_mv Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
title Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
spellingShingle Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
Lerfald, Maren
Cardiovascular
Cognition
Prevention
title_short Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
title_full Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
title_fullStr Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
title_full_unstemmed Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
title_sort Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
dc.creator.none.fl_str_mv Lerfald, Maren
Allore, Heather
Nilsen, Tom I. L.
Eldholm, Rannveig S.
Martínez Velilla, Nicolás
Selbæk, Geir
Ernstsen, Linda
author Lerfald, Maren
author_facet Lerfald, Maren
Allore, Heather
Nilsen, Tom I. L.
Eldholm, Rannveig S.
Martínez Velilla, Nicolás
Selbæk, Geir
Ernstsen, Linda
author_role author
author2 Allore, Heather
Nilsen, Tom I. L.
Eldholm, Rannveig S.
Martínez Velilla, Nicolás
Selbæk, Geir
Ernstsen, Linda
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Cardiovascular
Cognition
Prevention
topic Cardiovascular
Cognition
Prevention
description Background: High blood pressure and poor cardiorespiratory ftness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifable risk factors are associated with dementia risk. Methods: In this prospective cohort study, we used data from the population-based Trøndelag Health (HUNT) Study, Norway. We applied groupbased multidimensional trajectory modeling to identify age-specifc multidimensional trajectories of SBP, DBP, and estimated cardiorespiratory ftness across 3 surveys (HUNT1, 1984–1986 to HUNT3, 2006–2008). Dementia was diagnosed in the HUNT4 70+ substudy in 2017–2019. We used multivariate logistic regression to estimate odds ratios (ORs) and risk differences (RDs) of dementia. Results: In total, 7 594 participants (54.9% women) were included, with a mean age of 44.7 (SD 6.3) years at HUNT1. Dementia was diagnosed in 1 062 (14.0%) participants. We identifed 2 multidimensional trajectories throughout adulthood within 3 age groups: one with higher systolic blood pressure (SBP) and diastolic blood pressure (DBP), and lower estimated cardiorespiratory ftness (the poorer group), and one with lower SBP and DBP, and higher cardiorespiratory ftness (the better group). After adjustment for sex, apolipoprotein E ε4 status, education, marital status, and diabetes, the better group had consistently lower risk of dementia in all age groups with the lowest OR in the middle-aged group of 0.63 (95% confdence intervals [95% CI]: 0.51, 0.78) with corresponding RD of −0.07 (95% CI: −0.10, −0.04). Conclusions: Having a benefcial multidimensional trajectory of SBP, DBP, and cardiorespiratory ftness in adulthood was associated with reduced dementia risk. Aiming for optimal SBP, DBP, and estimated cardiorespiratory ftness throughout adulthood may reduce dementia risk.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/52105
url https://hdl.handle.net/2454/52105
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/msword
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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