Longitudinal patterns of systolic blood pressure, diastolic blood pressure, cardiorespiratory fitness, and their association with dementia risk: the HUNT study
Background: High blood pressure and poor cardiorespiratory ftness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifable risk factors are associated with dementia risk. Methods: In this prospective cohort study, we used data...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/52105 |
| Acceso en línea: | https://hdl.handle.net/2454/52105 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardiovascular Cognition Prevention |
| Sumario: | Background: High blood pressure and poor cardiorespiratory ftness are independent risk factors for dementia. However, few studies have examined if combined longitudinal patterns of these modifable risk factors are associated with dementia risk. Methods: In this prospective cohort study, we used data from the population-based Trøndelag Health (HUNT) Study, Norway. We applied groupbased multidimensional trajectory modeling to identify age-specifc multidimensional trajectories of SBP, DBP, and estimated cardiorespiratory ftness across 3 surveys (HUNT1, 1984–1986 to HUNT3, 2006–2008). Dementia was diagnosed in the HUNT4 70+ substudy in 2017–2019. We used multivariate logistic regression to estimate odds ratios (ORs) and risk differences (RDs) of dementia. Results: In total, 7 594 participants (54.9% women) were included, with a mean age of 44.7 (SD 6.3) years at HUNT1. Dementia was diagnosed in 1 062 (14.0%) participants. We identifed 2 multidimensional trajectories throughout adulthood within 3 age groups: one with higher systolic blood pressure (SBP) and diastolic blood pressure (DBP), and lower estimated cardiorespiratory ftness (the poorer group), and one with lower SBP and DBP, and higher cardiorespiratory ftness (the better group). After adjustment for sex, apolipoprotein E ε4 status, education, marital status, and diabetes, the better group had consistently lower risk of dementia in all age groups with the lowest OR in the middle-aged group of 0.63 (95% confdence intervals [95% CI]: 0.51, 0.78) with corresponding RD of −0.07 (95% CI: −0.10, −0.04). Conclusions: Having a benefcial multidimensional trajectory of SBP, DBP, and cardiorespiratory ftness in adulthood was associated with reduced dementia risk. Aiming for optimal SBP, DBP, and estimated cardiorespiratory ftness throughout adulthood may reduce dementia risk. |
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