α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach
α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for m...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2009 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/665374 |
| Acceso en línea: | http://hdl.handle.net/10486/665374 https://dx.doi.org/10.2174/138955709789957422 |
| Access Level: | acceso abierto |
| Palabra clave: | α-N-heterocyclic thiosemicarbazone Antitumour agents Bis(thiosemicarbazone) Metal complexes Ribonucleotide reductase inhibitors Structure-activity relationships Química |
| Sumario: | α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships |
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