Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines

Introduction: Combining natural antioxidants with nanozymes represents a promising strategy to enhance therapeutic outcomes in oxidative stress-related diseases. This study integrates quercetin (Que), a plant-derived flavonoid with strong antioxidant activity, and cerium oxide nanozymes (CeO<inf&...

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Autores: Zhou, Shanlei, Zhang, Yu, Casals, Eudald, Zhang, Bo, Casals, Gregori, Zeng, Muling, Morales Ruiz, Manuel, Liu, Qingshi
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::04a9facc9be574fedf17e697e09d7788
Acesso em linha:http://hdl.handle.net/10261/432051
https://api.elsevier.com/content/abstract/scopus_id/105009486718
Access Level:acceso abierto
Palavra-chave:Cerium oxide nanoparticles
Chronic inflammation
Nanozymes
Oxidative stress
Quercetin
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spelling Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory CytokinesZhou, ShanleiZhang, YuCasals, EudaldZhang, BoCasals, GregoriZeng, MulingMorales Ruiz, ManuelLiu, QingshiCerium oxide nanoparticlesChronic inflammationNanozymesOxidative stressQuercetinIntroduction: Combining natural antioxidants with nanozymes represents a promising strategy to enhance therapeutic outcomes in oxidative stress-related diseases. This study integrates quercetin (Que), a plant-derived flavonoid with strong antioxidant activity, and cerium oxide nanozymes (CeO<inf>2</inf> NZs) into mesoporous silica (mSiO<inf>2</inf>) to enhance therapeutic efficacy and overcome the poor solubility and bioavailability of natural antioxidants. Methods: Large-pore mSiO₂ (11 nm) were synthesized via a sol–gel method to encapsulate cerium oxide nanozymes (CeO₂NZs). Que was loaded using solvent impregnation to obtain (CeO₂/Que)@mSiO₂ nanocomposites. Structural and chemical characterization was performed, and biological evaluations were conducted in A549 cells. Results: The incorporation of a large mesopore mSiO₂ (11 nm) significantly enhanced Que loading capacity and its sustained release in cell culture media. The (CeO₂/Que)@mSiO₂ nanocomposite demonstrated excellent biocompatibility, effective ROS scavenging, and significant downregulation of inflammatory cytokines (IL-1β, IL-6, TNF-α) compared to free Que. Conclusion: The (CeO₂/Que)@mSiO₂ nanoplatform offers synergistic antioxidant and anti-inflammatory effects, supporting its potential for treating oxidative stress-related inflammatory conditions.This work was supported by grants from the Research Funding for Doctoral Talents of the First Affiliated Hospital of Anhui Medical University (grant No.1952); the Instituto de Salud Carlos III (PI24/00688 and BA22/00017 to G. C.), co-financed by FEDER, European Union, “A way of making Europe”; Agencia Estatal de Investigación (Project PID2022-138243OB-I00 funded by MICIU/AEI /10.13039/501100011033 and by FEDER, UE, to M.M.-R.). Consolidated Research Group, Departament de Recerca i Universitats de la Generalitat de Catalunya (2021 SGR 00881 to M.M.-R.). CIBERehd is financed by the Instituto de Salud Carlos III.With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2023-001263-S).Peer reviewedTaylor & FrancisInstituto de Salud Carlos IIIAgencia Estatal de Investigación (España)Generalitat de CatalunyaCasals, Eudald [0000-0002-2900-7295]Zeng, Muling [0000-0002-8627-4146]202620262025info:eu-repo/semantics/articlePublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/432051https://api.elsevier.com/content/abstract/scopus_id/105009486718reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138243OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2021-2023/CEX2023-001263-SInternational Journal of Nanomedicinehttp://doi.org/10.2147/IJN.S525411Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::04a9facc9be574fedf17e697e09d77882026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
title Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
spellingShingle Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
Zhou, Shanlei
Cerium oxide nanoparticles
Chronic inflammation
Nanozymes
Oxidative stress
Quercetin
title_short Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
title_full Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
title_fullStr Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
title_full_unstemmed Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
title_sort Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
dc.creator.none.fl_str_mv Zhou, Shanlei
Zhang, Yu
Casals, Eudald
Zhang, Bo
Casals, Gregori
Zeng, Muling
Morales Ruiz, Manuel
Liu, Qingshi
author Zhou, Shanlei
author_facet Zhou, Shanlei
Zhang, Yu
Casals, Eudald
Zhang, Bo
Casals, Gregori
Zeng, Muling
Morales Ruiz, Manuel
Liu, Qingshi
author_role author
author2 Zhang, Yu
Casals, Eudald
Zhang, Bo
Casals, Gregori
Zeng, Muling
Morales Ruiz, Manuel
Liu, Qingshi
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Agencia Estatal de Investigación (España)
Generalitat de Catalunya
Casals, Eudald [0000-0002-2900-7295]
Zeng, Muling [0000-0002-8627-4146]
dc.subject.none.fl_str_mv Cerium oxide nanoparticles
Chronic inflammation
Nanozymes
Oxidative stress
Quercetin
topic Cerium oxide nanoparticles
Chronic inflammation
Nanozymes
Oxidative stress
Quercetin
description Introduction: Combining natural antioxidants with nanozymes represents a promising strategy to enhance therapeutic outcomes in oxidative stress-related diseases. This study integrates quercetin (Que), a plant-derived flavonoid with strong antioxidant activity, and cerium oxide nanozymes (CeO<inf>2</inf> NZs) into mesoporous silica (mSiO<inf>2</inf>) to enhance therapeutic efficacy and overcome the poor solubility and bioavailability of natural antioxidants. Methods: Large-pore mSiO₂ (11 nm) were synthesized via a sol–gel method to encapsulate cerium oxide nanozymes (CeO₂NZs). Que was loaded using solvent impregnation to obtain (CeO₂/Que)@mSiO₂ nanocomposites. Structural and chemical characterization was performed, and biological evaluations were conducted in A549 cells. Results: The incorporation of a large mesopore mSiO₂ (11 nm) significantly enhanced Que loading capacity and its sustained release in cell culture media. The (CeO₂/Que)@mSiO₂ nanocomposite demonstrated excellent biocompatibility, effective ROS scavenging, and significant downregulation of inflammatory cytokines (IL-1β, IL-6, TNF-α) compared to free Que. Conclusion: The (CeO₂/Que)@mSiO₂ nanoplatform offers synergistic antioxidant and anti-inflammatory effects, supporting its potential for treating oxidative stress-related inflammatory conditions.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/432051
https://api.elsevier.com/content/abstract/scopus_id/105009486718
url http://hdl.handle.net/10261/432051
https://api.elsevier.com/content/abstract/scopus_id/105009486718
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138243OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2021-2023/CEX2023-001263-S
International Journal of Nanomedicine
http://doi.org/10.2147/IJN.S525411
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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