Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings

The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with memory performance. In the control group,...

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Authors: Sánchez Torres, Ana María, Basterra, Virginia, Rosa, Araceli, Fañanás, Lourdes, Zarzuela, Amalia, Ibáñez, Berta, Peralta Martín, Víctor, Cuesta, Manuel J.
Format: article
Status:Versión aceptada para publicación
Publication Date:2013
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/47228
Online Access:https://hdl.handle.net/2454/47228
Access Level:Open access
Keyword:Schizophrenia spectrum disorders
Cognition
Cannabis
Longitudinal
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spelling Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblingsSánchez Torres, Ana MaríaBasterra, VirginiaRosa, AraceliFañanás, LourdesZarzuela, AmaliaIbáñez, BertaPeralta Martín, VíctorCuesta, Manuel J.Schizophrenia spectrum disordersCognitionCannabisLongitudinalThe relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with memory performance. In the control group, cannabis use per se did not predict cognitive performance; however, when adding lifetime tobacco use to the model, we found a negative association between lifetime cannabis and tobacco use and processing speed and social cognition performance. Moreover, a lower IQ associated with current cannabis use predicted worse attentional performance in the control group. The differential pattern of associations between cannabis use and cognitive performance in patients compared with siblings and controls can be explained by the negative impact of illness on cognition. schizophrenia spectrum disorders who use cannabis. The aim of this study was to determine the relationship between lifetime cannabis use, as assessed longitudinally over 10 years of follow-up in a sample of 42 patients and 35 of their unaffected siblings, and current cognitive performance. Forty-two healthy control subjects were assessed at follow-up with the same instruments. Stepwise linear regression revealed a negative effect of longitudinal cannabis use on performance in a social cognition task in the patient group. In the sibling group, lifetime cannabis use had a negative effect on processing speed and declarativeThis study was partly funded by “Plan Nacional sobre Drogas” (Grant 2008/I/030; Grant 2008/090), SAF2008-05674-C01-C02; Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (2009SGR827), the Department of Health of the Government of Navarra (Grant 55/2007) and the ‘Carlos III Health Institute’ (FEDER Funds) from the Spanish Ministry of Health (Grant 08/I/1026).SpringerCiencias de la SaludOsasun Zientziak2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/47228reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglés© Springer-Verlag Berlin Heidelberg 2013info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/472282026-06-17T12:41:47Z
dc.title.none.fl_str_mv Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
title Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
spellingShingle Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
Sánchez Torres, Ana María
Schizophrenia spectrum disorders
Cognition
Cannabis
Longitudinal
title_short Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
title_full Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
title_fullStr Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
title_full_unstemmed Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
title_sort Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
dc.creator.none.fl_str_mv Sánchez Torres, Ana María
Basterra, Virginia
Rosa, Araceli
Fañanás, Lourdes
Zarzuela, Amalia
Ibáñez, Berta
Peralta Martín, Víctor
Cuesta, Manuel J.
author Sánchez Torres, Ana María
author_facet Sánchez Torres, Ana María
Basterra, Virginia
Rosa, Araceli
Fañanás, Lourdes
Zarzuela, Amalia
Ibáñez, Berta
Peralta Martín, Víctor
Cuesta, Manuel J.
author_role author
author2 Basterra, Virginia
Rosa, Araceli
Fañanás, Lourdes
Zarzuela, Amalia
Ibáñez, Berta
Peralta Martín, Víctor
Cuesta, Manuel J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Schizophrenia spectrum disorders
Cognition
Cannabis
Longitudinal
topic Schizophrenia spectrum disorders
Cognition
Cannabis
Longitudinal
description The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with memory performance. In the control group, cannabis use per se did not predict cognitive performance; however, when adding lifetime tobacco use to the model, we found a negative association between lifetime cannabis and tobacco use and processing speed and social cognition performance. Moreover, a lower IQ associated with current cannabis use predicted worse attentional performance in the control group. The differential pattern of associations between cannabis use and cognitive performance in patients compared with siblings and controls can be explained by the negative impact of illness on cognition. schizophrenia spectrum disorders who use cannabis. The aim of this study was to determine the relationship between lifetime cannabis use, as assessed longitudinally over 10 years of follow-up in a sample of 42 patients and 35 of their unaffected siblings, and current cognitive performance. Forty-two healthy control subjects were assessed at follow-up with the same instruments. Stepwise linear regression revealed a negative effect of longitudinal cannabis use on performance in a social cognition task in the patient group. In the sibling group, lifetime cannabis use had a negative effect on processing speed and declarative
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/47228
url https://hdl.handle.net/2454/47228
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv © Springer-Verlag Berlin Heidelberg 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Springer-Verlag Berlin Heidelberg 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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