Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination efforts. We developed a simple and robust - Phone...

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Detalhes bibliográficos
Autores: Young, Rodrigo M.|||0000-0001-5765-197X, Solis, Camila J.|||0000-0002-7195-523X, Barriga-Fehrman, Andres, Abogabir, Carlos, Thadani, Alvaro R.|||0000-0002-2541-1709, Labarca, Mariana|||0000-0001-6455-3569, Bustamante, Eva|||0000-0002-3125-8608, Tapia, Cecilia V|||0000-0001-6234-2100, Sarda, Antonia G., Sepulveda, Francisca|||0000-0002-8144-0096, Pozas, Nadia, Cerpa, Leslie C.|||0000-0002-9525-389X, Lavanderos, María A.|||0000-0001-6167-0508, Varela, Nelson M.|||0000-0002-5229-3007, Santibañez, Alvaro|||0000-0001-9330-2961, Sandino, Ana María|||0000-0002-3862-3743, Reyes-López, Felipe E.|||0000-0002-5001-457X, Dixon, Garth|||0000-0001-8165-3094, Quiñones, Luis A.|||0000-0002-7967-5320
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256402
Acesso em linha:https://ddd.uab.cat/record/256402
https://dx.doi.org/urn:doi:10.7554/eLife.70333
Access Level:acceso abierto
Palavra-chave:COVID-19
SARS-CoV-2
RT-PCR
Virus
Descrição
Resumo:The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination efforts. We developed a simple and robust - Phone Screen Testing (PoST) - method to detect SARS-CoV-2-positive individuals by RT-PCR testing of smartphone screen swab samples. We show that 81.3-100% of individuals with high-viral-load SARS-CoV-2 nasopharyngeal-positive samples also test positive for PoST, suggesting this method is effective in identifying COVID-19 contagious individuals. Furthermore, we successfully identified polymorphisms associated with SARS-CoV-2 Alpha, Beta, and Gamma variants, in SARS-CoV-2-positive PoST samples. Overall, we report that PoST is a new non-invasive, cost-effective, and easy-to-implement smartphone-based smart alternative for SARS-CoV-2 testing, which could help to contain COVID-19 outbreaks and identification of variants of concern in the years to come.

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