Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source

[EN] Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of...

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Autores: Peñas, Juan, Alejo, Aaron, Bembibre, Adrian, Apiñaniz, Jon Imanol, García-García, Enrique, Guerrero, Carlos, Henares, José Luis, Hernández-Palmero, Irene, Méndez, Cruz, Millán-Callado, María Ángeles, Puyuelo-Valdés, Pilar, Benlliure, José, Seimetz, Michael
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/220784
Acceso en línea:https://riunet.upv.es/handle/10251/220784
Access Level:acceso abierto
Palabra clave:Carbon-11
Positron-emission tomography (PET)
Proton source
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oai_identifier_str oai:riunet.upv.es:10251/220784
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
title Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
spellingShingle Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
Peñas, Juan
Carbon-11
Positron-emission tomography (PET)
Proton source
title_short Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
title_full Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
title_fullStr Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
title_full_unstemmed Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
title_sort Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
dc.creator.none.fl_str_mv Peñas, Juan
Alejo, Aaron
Bembibre, Adrian
Apiñaniz, Jon Imanol
García-García, Enrique
Guerrero, Carlos
Henares, José Luis
Hernández-Palmero, Irene
Méndez, Cruz
Millán-Callado, María Ángeles
Puyuelo-Valdés, Pilar
Benlliure, José
Seimetz, Michael
author Peñas, Juan
author_facet Peñas, Juan
Alejo, Aaron
Bembibre, Adrian
Apiñaniz, Jon Imanol
García-García, Enrique
Guerrero, Carlos
Henares, José Luis
Hernández-Palmero, Irene
Méndez, Cruz
Millán-Callado, María Ángeles
Puyuelo-Valdés, Pilar
Benlliure, José
Seimetz, Michael
author_role author
author2 Alejo, Aaron
Bembibre, Adrian
Apiñaniz, Jon Imanol
García-García, Enrique
Guerrero, Carlos
Henares, José Luis
Hernández-Palmero, Irene
Méndez, Cruz
Millán-Callado, María Ángeles
Puyuelo-Valdés, Pilar
Benlliure, José
Seimetz, Michael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Instrumentación para Imagen Molecular
Xunta de Galicia
Generalitat Valenciana
Agencia Estatal de Investigación
European Regional Development Fund
Ministerio de Ciencia e Innovación
Ministerio de Ciencia, Innovación y Universidades
Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Carbon-11
Positron-emission tomography (PET)
Proton source
topic Carbon-11
Positron-emission tomography (PET)
Proton source
description [EN] Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the frst time the use of a high-repetition rate, ultraintense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10¿14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11B(p,n)11C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Signifcant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-theart technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-05-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/220784
url https://riunet.upv.es/handle/10251/220784
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-098117-B-C21 NEUTRONES, INSTRUMENTACION NUCLEAR E INVESTIGACION RELACIONADA CON TERAPIA CON PROTONES EN EL CNA E INSTALACIONES INTERNACIONALES
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-101578-B-C21 APLICACIONES MEDICAS DE LOS ACELERADORES LASER
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-101578-B-C22 EFECTOS RADIOBIOLOGICOS DE PULSOS DE PARTICULAS ULTRA-INTENSOS EN CELULAS VIVAS
Generalitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2020%2F207 Efectos radiobiológicos de pulsos ultra-cortos de iones en células vivas
Xunta de Galicia http://dx.doi.org/10.13039/501100010801 ED431F2023%2F21
Xunta de Galicia http://dx.doi.org/10.13039/501100010801 ED431C 2017%2F54
Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2021-032654-I
Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 MDM-2016-0692
Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona LCF%2FBQ%2FPI20%2F11760027
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 BES-2017-08917
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton sourcePeñas, JuanAlejo, AaronBembibre, AdrianApiñaniz, Jon ImanolGarcía-García, EnriqueGuerrero, CarlosHenares, José LuisHernández-Palmero, IreneMéndez, CruzMillán-Callado, María ÁngelesPuyuelo-Valdés, PilarBenlliure, JoséSeimetz, MichaelCarbon-11Positron-emission tomography (PET)Proton source[EN] Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the frst time the use of a high-repetition rate, ultraintense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10¿14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11B(p,n)11C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Signifcant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-theart technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.This work has received financial support by the Maria de Maetzu Units of Excellence program MDM-2016-0692-17-2, and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under RTI2018-098117-B-C21, RTI2018-101578-B-C21, RTI2018-101578-B-C22, and FPI predoctoral BES-2017-08917 grants, and the Xunta de Galicia grants GRC ED431C 2017/54 and ED431F2023/21. It also was supported by Generalitat Valenciana, grant AICO/2020/207. Action co-financied by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER). This work was supported by 'la Caixa' Foundation (ID 100010434) [fellowship code LCF/BQ/PI20/11760027], and grant RYC2021-032654-I funded by MCIN, AEI and by 'European Union NextGenerationEU'.Nature Publishing GroupInstituto de Instrumentación para Imagen MolecularXunta de GaliciaGeneralitat ValencianaAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Ciencia e InnovaciónMinisterio de Ciencia, Innovación y UniversidadesFundació Bancària Caixa d'Estalvis i Pensions de BarcelonaRepositorio Institucional de la Universitat Politècnica de València Riunet20242024-05-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/220784reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-098117-B-C21 NEUTRONES, INSTRUMENTACION NUCLEAR E INVESTIGACION RELACIONADA CON TERAPIA CON PROTONES EN EL CNA E INSTALACIONES INTERNACIONALESAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-101578-B-C21 APLICACIONES MEDICAS DE LOS ACELERADORES LASERAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-101578-B-C22 EFECTOS RADIOBIOLOGICOS DE PULSOS DE PARTICULAS ULTRA-INTENSOS EN CELULAS VIVASGeneralitat Valenciana https://doi.org/10.13039/501100003359 AICO%2F2020%2F207 Efectos radiobiológicos de pulsos ultra-cortos de iones en células vivasXunta de Galicia http://dx.doi.org/10.13039/501100010801 ED431F2023%2F21Xunta de Galicia http://dx.doi.org/10.13039/501100010801 ED431C 2017%2F54Ministerio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 RYC2021-032654-IMinisterio de Ciencia, Innovación y Universidades https://doi.org/10.13039/100014440 MDM-2016-0692Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona LCF%2FBQ%2FPI20%2F11760027Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 BES-2017-08917open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2207842026-06-13T07:49:27Z
score 15.811543

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