Pathological mineralization of calcium phosphate

[eng] Based on the study of non-infected calcium phosphate renal calculi, solid concretions formed in simulated body fluid and calcific deposits formed in human aortic valves, two different mechanisms of hydroxyapatite (HAP) formation are described. In a mechanism, the formation of...

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Detalhes bibliográficos
Autores: Grases Freixedas, Felicià, Sohnel, Otakar
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Universidad de las Islas Baleares
Repositorio:Biblioteca Digital de les Illes Balears
OAI Identifier:medicinaBalear:Medicina_Balear_2015v30n1_p043
Acesso em linha:http://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/Medicina/_Balear_/2015v30n/1_p043.dir/Medicina_Balear_2015v30n1_p043.pdf
http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/Medicina_Balear_2015v30n1_p043
Access Level:acceso abierto
Palavra-chave:Kidneys Calculi
Medical sciences
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spelling Pathological mineralization of calcium phosphateGrases Freixedas, FeliciàSohnel, OtakarKidneys CalculiMedical sciences[eng] Based on the study of non-infected calcium phosphate renal calculi, solid concretions formed in simulated body fluid and calcific deposits formed in human aortic valves, two different mechanisms of hydroxyapatite (HAP) formation are described. In a mechanism, the formation of spherical HAP particles takes place via aggregation of Posner’s clusters present in the liquid, after reaching a certain size gradually settled in the liquid and became incorporated into developing concretion. In the other mechanism, the microcolumnar HAP crystals were nucleated on randomly distributed detritus of organic origin embedded in the compact phase. Keywords: Biological hydroxyapatite, formation mechanism, renal calculi, aortic valve, body fluid[spa] Basándonos en estudios de los cálculos renales no infecciosos, concreciones sólidas obtenidas in vitro utilizando fluidos biológicos simulados y depósitos calcificados formados en válvulas aórticas humanas, se describen dos mecanismos diferentes que explican el desarrollo de la hidroxiapatita (HAP). En uno de los mecanismos, la formación de nanopartículas esféricas de HAP tiene lugar a través de la agregación de macroespecies de Posner presentes en el líquido, que a su vez se agrupan mediante nucleación superficial formando concreciones de mayor tamaño. En el otro mecanismo, la formación de cristales microcolumnares de HAP tiene lugar mediante procesos de nucleación heterogénea sobre detritus de materia orgánica localizados en espacios confinados y poco irrigados. Palabras clave: Hidroxiapatita biológica, mecanismo de formación, cálculo renal, vávula aórtica, fluido biológicoReial Acadèmia de Medicina de les Illes Balears2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/Medicina/_Balear_/2015v30n/1_p043.dir/Medicina_Balear_2015v30n1_p043.pdfhttp://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/Medicina_Balear_2015v30n1_p043reponame:Biblioteca Digital de les Illes Balearsinstname:Universidad de las Islas BalearesInglésMedicina Balear 2015, Vol. 30, N. 1, pp. 43-46All rights reservedinfo:eu-repo/semantics/openAccessmedicinaBalear:Medicina_Balear_2015v30n1_p0432026-05-28T12:40:11Z
dc.title.none.fl_str_mv Pathological mineralization of calcium phosphate
title Pathological mineralization of calcium phosphate
spellingShingle Pathological mineralization of calcium phosphate
Grases Freixedas, Felicià
Kidneys Calculi
Medical sciences
title_short Pathological mineralization of calcium phosphate
title_full Pathological mineralization of calcium phosphate
title_fullStr Pathological mineralization of calcium phosphate
title_full_unstemmed Pathological mineralization of calcium phosphate
title_sort Pathological mineralization of calcium phosphate
dc.creator.none.fl_str_mv Grases Freixedas, Felicià
Sohnel, Otakar
author Grases Freixedas, Felicià
author_facet Grases Freixedas, Felicià
Sohnel, Otakar
author_role author
author2 Sohnel, Otakar
author2_role author
dc.subject.none.fl_str_mv Kidneys Calculi
Medical sciences
topic Kidneys Calculi
Medical sciences
description [eng] Based on the study of non-infected calcium phosphate renal calculi, solid concretions formed in simulated body fluid and calcific deposits formed in human aortic valves, two different mechanisms of hydroxyapatite (HAP) formation are described. In a mechanism, the formation of spherical HAP particles takes place via aggregation of Posner’s clusters present in the liquid, after reaching a certain size gradually settled in the liquid and became incorporated into developing concretion. In the other mechanism, the microcolumnar HAP crystals were nucleated on randomly distributed detritus of organic origin embedded in the compact phase. Keywords: Biological hydroxyapatite, formation mechanism, renal calculi, aortic valve, body fluid
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/Medicina/_Balear_/2015v30n/1_p043.dir/Medicina_Balear_2015v30n1_p043.pdf
http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/Medicina_Balear_2015v30n1_p043
url http://ibdigital.uib.es/greenstone/sites/oai-site/collect/medicinaBalear/index/assoc/Medicina/_Balear_/2015v30n/1_p043.dir/Medicina_Balear_2015v30n1_p043.pdf
http://ibdigital.uib.es/greenstone/library/collection/medicinaBalear/document/Medicina_Balear_2015v30n1_p043
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Medicina Balear 2015, Vol. 30, N. 1, pp. 43-46
dc.rights.none.fl_str_mv All rights reserved
info:eu-repo/semantics/openAccess
rights_invalid_str_mv All rights reserved
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Reial Acadèmia de Medicina de les Illes Balears
publisher.none.fl_str_mv Reial Acadèmia de Medicina de les Illes Balears
dc.source.none.fl_str_mv reponame:Biblioteca Digital de les Illes Balears
instname:Universidad de las Islas Baleares
instname_str Universidad de las Islas Baleares
reponame_str Biblioteca Digital de les Illes Balears
collection Biblioteca Digital de les Illes Balears
repository.name.fl_str_mv
repository.mail.fl_str_mv
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