Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages

Producción Científica

Detalhes bibliográficos
Autores: López Urrutia, Luis, Alonso, Andrés, Nieto, Maria Luisa, Bayón Prieto, Yolanda, Orduña Domingo, Antonio, Sánchez Crespo, Mariano
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:España
Recursos:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/47499
Acesso em linha:https://doi.org/10.1128/IAI.68.3.1740-1745.2000
https://uvadoc.uva.es/handle/10324/47499
Access Level:acceso abierto
Palavra-chave:Lipopolisacáridos
Lipopolysaccharides
Brucella abortus
Brucella melitensis
Macrófagos
Macrophages
24 Ciencias de la Vida
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spelling Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophagesLópez Urrutia, LuisAlonso, AndrésNieto, Maria LuisaBayón Prieto, YolandaOrduña Domingo, AntonioSánchez Crespo, MarianoLipopolisacáridosLipopolysaccharidesBrucella abortusBrucella melitensisMacrófagosMacrophages24 Ciencias de la VidaProducción CientíficaSmooth lipopolysaccharide (S-LPS) and lipid A of Brucella abortus and Brucella melitensis induced the production of nitric oxide (NO) by rat adherent peritoneal cells, but they induced lower levels of production of NO than Escherichia coli LPS. The participation of the inducible isoform of NO synthase (iNOS) was confirmed by the finding of an increased expression of both iNOS mRNA and iNOS protein. These observations might help to explain (i) the acute outcome of Brucella infection in rodents, (ii) the low frequency of septic shock in human brucellosis, and (iii) the prolonged intracellular survival of Brucella in humans.This work was supported by (grants FIS 96/1017, SAF96-0144, and SAF98-0176)American Society for Microbiology2000info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1128/IAI.68.3.1740-1745.2000https://uvadoc.uva.es/handle/10324/47499reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://journals.asm.org/doi/10.1128/IAI.68.3.1740-1745.2000info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/474992026-06-13T12:44:47Z
dc.title.none.fl_str_mv Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
title Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
spellingShingle Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
López Urrutia, Luis
Lipopolisacáridos
Lipopolysaccharides
Brucella abortus
Brucella melitensis
Macrófagos
Macrophages
24 Ciencias de la Vida
title_short Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
title_full Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
title_fullStr Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
title_full_unstemmed Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
title_sort Lipopolysaccharides of brucella abortus and brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages
dc.creator.none.fl_str_mv López Urrutia, Luis
Alonso, Andrés
Nieto, Maria Luisa
Bayón Prieto, Yolanda
Orduña Domingo, Antonio
Sánchez Crespo, Mariano
author López Urrutia, Luis
author_facet López Urrutia, Luis
Alonso, Andrés
Nieto, Maria Luisa
Bayón Prieto, Yolanda
Orduña Domingo, Antonio
Sánchez Crespo, Mariano
author_role author
author2 Alonso, Andrés
Nieto, Maria Luisa
Bayón Prieto, Yolanda
Orduña Domingo, Antonio
Sánchez Crespo, Mariano
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lipopolisacáridos
Lipopolysaccharides
Brucella abortus
Brucella melitensis
Macrófagos
Macrophages
24 Ciencias de la Vida
topic Lipopolisacáridos
Lipopolysaccharides
Brucella abortus
Brucella melitensis
Macrófagos
Macrophages
24 Ciencias de la Vida
description Producción Científica
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1128/IAI.68.3.1740-1745.2000
https://uvadoc.uva.es/handle/10324/47499
url https://doi.org/10.1128/IAI.68.3.1740-1745.2000
https://uvadoc.uva.es/handle/10324/47499
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://journals.asm.org/doi/10.1128/IAI.68.3.1740-1745.2000
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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