Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels

This article belongs to the Section Biochemistry.

Detalles Bibliográficos
Autores: Lopes de Oliveira, Isadora, Domínguez-Rodríguez, Gloria, Montero, Lidia, Viganó, Juliane, Cifuentes, Alejandro, Arial Rostagno, Mauricio, Ibáñez, Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/372671
Acceso en línea:http://hdl.handle.net/10261/372671
Access Level:acceso abierto
Palabra clave:Ellagic acid
α-punicalagin
β-punicalagin
Natural deep eutectic solvents
Ultrasonic-assisted extraction
Pressurized liquid extraction
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spelling Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peelsLopes de Oliveira, IsadoraDomínguez-Rodríguez, GloriaMontero, LidiaViganó, JulianeCifuentes, AlejandroArial Rostagno, MauricioIbáñez, ElenaEllagic acidα-punicalaginβ-punicalaginNatural deep eutectic solventsUltrasonic-assisted extractionPressurized liquid extractionThis article belongs to the Section Biochemistry.Pomegranate (Punica granatum L.) peel is a potential source of bioactive phenolic compounds such as ellagic acid and α- and β-punicalagin. This work explores the efficiency of natural deep eutectic solvents combined with ultrasound-assisted extraction (UAE) and pressurized liquid extraction (PLE) for their extraction. Five NaDESs were evaluated by employing UAE (25 °C, for 50 min) to determine their total phenolic content (Folin–Ciocalteu assay) and ellagic acid and α- and β-punicalagin contents (high-performance liquid chromatography (HPLC-DAD)). The NaDES composed of choline chloride (ChCl) and glycerol (Gly) (1:2, molar ratio) was the most efficient in the UAE when compared with the rest of the NaDESs and water extracts. Therefore, ChCl:Gly was further evaluated using PLE at different temperatures (40, 80, 120 and 160 °C). The PLE-NaDES extract obtained at 80 °C for 20 min at 1500 psi exhibited the highest contents of ellagic acid and α- and β-punicalagin compared to the rest of the temperatures and PLE-water extracts obtained under the same extraction conditions. Combining UAE or PLE with a NaDES emerges as a sustainable alternative for extracting ellagic acid and α- and β-punicalagin from pomegranate peel.This research was supported by projects PID2020-113050RB-I00 and PDC2021-120814-I00 funded by MCIN/AEI/10.13039/501100011033 and the European Union’s Next-Generation EU/PRTR. In addition, this work was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo (grant numbers 2021/13638-0, 2022/13565-5, and 2018/14582-5), and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (grant numbers 302610/2021-9 9 and 402638/2023-9). Furthermore, this work was supported by the “Margarita Salas” grant of the University of Alcalá for G.D.-R. and the “Ramon y Cajal” grant RYC2021-033148-I funded by MCIN/AEI/10.13039/501100011033 for L.M.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionFundação de Amparo à Pesquisa do Estado de São PauloConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/372671reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113050RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-120814-I00info:eu-repo/grantAgreement/AEI//RYC2021-033148-IThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/ijms25189992https://doi.org/10.3390/ijms25189992Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3726712026-05-22T06:33:51Z
dc.title.none.fl_str_mv Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
title Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
spellingShingle Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
Lopes de Oliveira, Isadora
Ellagic acid
α-punicalagin
β-punicalagin
Natural deep eutectic solvents
Ultrasonic-assisted extraction
Pressurized liquid extraction
title_short Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
title_full Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
title_fullStr Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
title_full_unstemmed Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
title_sort Advanced extraction techniques combined with natural deep eutectic solvents for extracting phenolic compounds from pomegranate (Punica granatum L.) peels
dc.creator.none.fl_str_mv Lopes de Oliveira, Isadora
Domínguez-Rodríguez, Gloria
Montero, Lidia
Viganó, Juliane
Cifuentes, Alejandro
Arial Rostagno, Mauricio
Ibáñez, Elena
author Lopes de Oliveira, Isadora
author_facet Lopes de Oliveira, Isadora
Domínguez-Rodríguez, Gloria
Montero, Lidia
Viganó, Juliane
Cifuentes, Alejandro
Arial Rostagno, Mauricio
Ibáñez, Elena
author_role author
author2 Domínguez-Rodríguez, Gloria
Montero, Lidia
Viganó, Juliane
Cifuentes, Alejandro
Arial Rostagno, Mauricio
Ibáñez, Elena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ellagic acid
α-punicalagin
β-punicalagin
Natural deep eutectic solvents
Ultrasonic-assisted extraction
Pressurized liquid extraction
topic Ellagic acid
α-punicalagin
β-punicalagin
Natural deep eutectic solvents
Ultrasonic-assisted extraction
Pressurized liquid extraction
description This article belongs to the Section Biochemistry.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/372671
url http://hdl.handle.net/10261/372671
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113050RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-120814-I00
info:eu-repo/grantAgreement/AEI//RYC2021-033148-I
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/ijms25189992
https://doi.org/10.3390/ijms25189992
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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