Semantic verbal fluency pattern, dementia rating scores and adaptive behavior correlate with plasma Aß42 concentrations in down syndrome young adults
© 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/82928 |
| Acceso en línea: | https://hdl.handle.net/2117/82928 https://dx.doi.org/10.3389/fnbeh.2015.00301 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomathematics Alzheimer’s disease Amyloid precursor protein Aß Communication skills DMR Down syndrome Semantic verbal fluency Switching Biologia -- Models matemàtics Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències |
| Sumario: | © 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer’s disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of Aß peptides (Aß40 and Aß42), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma Aß42 concentrations, a higher DMR score and impaired communication skills (ABAS–II). The total word production and switching ability in SVFT were good indicators of plasma Aß42 concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS. |
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