From A to m6A: the emerging viral epitranscriptome

There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nucl...

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Detalles Bibliográficos
Autores: Baquero Pérez, Belinda, Geers, Daryl, Díez Antón, Juana, 1962-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/47945
Acceso en línea:http://hdl.handle.net/10230/47945
http://dx.doi.org/10.3390/v13061049
Access Level:acceso abierto
Palabra clave:m6A
Viral infection
Epitranscriptomics
RNA modification
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spelling From A to m6A: the emerging viral epitranscriptomeBaquero Pérez, BelindaGeers, DarylDíez Antón, Juana, 1962-m6AViral infectionEpitranscriptomicsRNA modificationThere are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m6A modifications play important roles in regulating viral replication by interacting with the cellular m6A machinery. In this review, we will exhaustively detail the current knowledge on m6A modification, with an emphasis on its function in virus biology.This work was supported by the Spanish Ministry of Science and Innovation through grants PID2019-106959RB-I00/AEI/10.13039/501100011033, an institutional “Maria de Maeztu” Programme for Units of Excellence in R&D (CEX2018-000792-M), by the 2017 SGR 909 grant from the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement of the Generalitat de Catalunya and a Beatriu Pinós postdoctoral fellowship awarded to Belinda Baquero-Perez which is funded by the Secretary of Universities and Research (Government of Catalonia) and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie grant agreement No 801370. All figures in this review were drawn using BioRender.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47945http://dx.doi.org/10.3390/v13061049reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésViruses. 2021;13(6):1049info:eu-repo/grantAgreement/EC/H2020/801370© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/479452026-06-12T07:21:37Z
dc.title.none.fl_str_mv From A to m6A: the emerging viral epitranscriptome
title From A to m6A: the emerging viral epitranscriptome
spellingShingle From A to m6A: the emerging viral epitranscriptome
Baquero Pérez, Belinda
m6A
Viral infection
Epitranscriptomics
RNA modification
title_short From A to m6A: the emerging viral epitranscriptome
title_full From A to m6A: the emerging viral epitranscriptome
title_fullStr From A to m6A: the emerging viral epitranscriptome
title_full_unstemmed From A to m6A: the emerging viral epitranscriptome
title_sort From A to m6A: the emerging viral epitranscriptome
dc.creator.none.fl_str_mv Baquero Pérez, Belinda
Geers, Daryl
Díez Antón, Juana, 1962-
author Baquero Pérez, Belinda
author_facet Baquero Pérez, Belinda
Geers, Daryl
Díez Antón, Juana, 1962-
author_role author
author2 Geers, Daryl
Díez Antón, Juana, 1962-
author2_role author
author
dc.subject.none.fl_str_mv m6A
Viral infection
Epitranscriptomics
RNA modification
topic m6A
Viral infection
Epitranscriptomics
RNA modification
description There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m6A modifications play important roles in regulating viral replication by interacting with the cellular m6A machinery. In this review, we will exhaustively detail the current knowledge on m6A modification, with an emphasis on its function in virus biology.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/47945
http://dx.doi.org/10.3390/v13061049
url http://hdl.handle.net/10230/47945
http://dx.doi.org/10.3390/v13061049
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Viruses. 2021;13(6):1049
info:eu-repo/grantAgreement/EC/H2020/801370
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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