PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors

The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applicat...

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Authors: Lopez-Larrea, N., Wustoni, S., Peñas, Mario I., Uribe, J., Dominguez-Alfaro, A., Gallastegui, A., Inal, S., Mecerreyes, D.
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/372877
Online Access:http://hdl.handle.net/10261/372877
Access Level:Open access
Keyword:4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PE-DOT:PSS
PNIPAM
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spelling PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical TransistorsLopez-Larrea, N.Wustoni, S.Peñas, Mario I.Uribe, J.Dominguez-Alfaro, A.Gallastegui, A.Inal, S.Mecerreyes, D.4D printingdrug deliveryhydrogelsmultifunctionalityOECTsPE-DOT:PSSPNIPAMThe development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applications. The device relies on a conducting and thermo-responsive hydrogel made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and poly(N-isopropylacrylamide) (PNIPAM). This multifunctional hydrogel is 4D printable by Digital Light Processing (DLP) method and exhibits optimal biocompatibility. The hydrogel features a low critical solution temperature (LCST) ≈35 °C, above which its resistance changes dramatically due to the shrinkage it undergoes with temperature. The integration of PNIPAM/PEDOT hydrogel into an organic electrochemical transistor (OECT) as the gate electrode allows to generate a miniaturized bioelectronic device with a reversible response to temperature variations between 25 to 45 °C, along with high sensitivity of 0.05 °C. Furthermore, the PNIPAM/PEDOT hydrogel demonstrates its utility in drug delivery, achieving an Insulin-FITC release rate of 82 ± 4% at 37 °C, mimicking human body conditions. The hydrogel's functionality to store and release the insulin does not compromise its thermo-responsivity and the overall performance of the OECT. This multifunctional OECT opens new avenues for the development of customizable and personalized sensing and drug-delivery systems.This work was supported by the Marie Sklodowska-Curie Research and In- novation Staff Exchanges (RISE) under grant agreement No. 823989 “ION- BIKE”. Naroa Lopez-Larrea gratefully acknowledges the support from the Spanish Ministry of Universities (FPU20/03416). The authors thank Dr. Itx- aso Calafel (POLYMAT, UPV/EHU) for her support regarding rheological characterization and Jessica Parrado for OECT fabrication.Wiley-VCHMinisterio de Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/372877reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/HE/823989http://dx.doi.org/10.1002/adfm.202403708Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3728772026-05-22T06:33:51Z
dc.title.none.fl_str_mv PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
spellingShingle PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
Lopez-Larrea, N.
4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PE-DOT:PSS
PNIPAM
title_short PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_full PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_fullStr PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_full_unstemmed PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
title_sort PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
dc.creator.none.fl_str_mv Lopez-Larrea, N.
Wustoni, S.
Peñas, Mario I.
Uribe, J.
Dominguez-Alfaro, A.
Gallastegui, A.
Inal, S.
Mecerreyes, D.
author Lopez-Larrea, N.
author_facet Lopez-Larrea, N.
Wustoni, S.
Peñas, Mario I.
Uribe, J.
Dominguez-Alfaro, A.
Gallastegui, A.
Inal, S.
Mecerreyes, D.
author_role author
author2 Wustoni, S.
Peñas, Mario I.
Uribe, J.
Dominguez-Alfaro, A.
Gallastegui, A.
Inal, S.
Mecerreyes, D.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PE-DOT:PSS
PNIPAM
topic 4D printing
drug delivery
hydrogels
multifunctionality
OECTs
PE-DOT:PSS
PNIPAM
description The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applications. The device relies on a conducting and thermo-responsive hydrogel made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and poly(N-isopropylacrylamide) (PNIPAM). This multifunctional hydrogel is 4D printable by Digital Light Processing (DLP) method and exhibits optimal biocompatibility. The hydrogel features a low critical solution temperature (LCST) ≈35 °C, above which its resistance changes dramatically due to the shrinkage it undergoes with temperature. The integration of PNIPAM/PEDOT hydrogel into an organic electrochemical transistor (OECT) as the gate electrode allows to generate a miniaturized bioelectronic device with a reversible response to temperature variations between 25 to 45 °C, along with high sensitivity of 0.05 °C. Furthermore, the PNIPAM/PEDOT hydrogel demonstrates its utility in drug delivery, achieving an Insulin-FITC release rate of 82 ± 4% at 37 °C, mimicking human body conditions. The hydrogel's functionality to store and release the insulin does not compromise its thermo-responsivity and the overall performance of the OECT. This multifunctional OECT opens new avenues for the development of customizable and personalized sensing and drug-delivery systems.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/372877
url http://hdl.handle.net/10261/372877
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/HE/823989
http://dx.doi.org/10.1002/adfm.202403708
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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