PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applicat...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/372877 |
| Acceso en línea: | http://hdl.handle.net/10261/372877 |
| Access Level: | acceso abierto |
| Palabra clave: | 4D printing drug delivery hydrogels multifunctionality OECTs PE-DOT:PSS PNIPAM |
| Sumario: | The development of multifunctional organic materials represents a vibrant area of research, with applications spanning from biosensing to drug delivery. This study shows the development of a multifunctional bioelectronic device suitable for prolonged temperature monitoring and drug delivery applications. The device relies on a conducting and thermo-responsive hydrogel made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) and poly(N-isopropylacrylamide) (PNIPAM). This multifunctional hydrogel is 4D printable by Digital Light Processing (DLP) method and exhibits optimal biocompatibility. The hydrogel features a low critical solution temperature (LCST) ≈35 °C, above which its resistance changes dramatically due to the shrinkage it undergoes with temperature. The integration of PNIPAM/PEDOT hydrogel into an organic electrochemical transistor (OECT) as the gate electrode allows to generate a miniaturized bioelectronic device with a reversible response to temperature variations between 25 to 45 °C, along with high sensitivity of 0.05 °C. Furthermore, the PNIPAM/PEDOT hydrogel demonstrates its utility in drug delivery, achieving an Insulin-FITC release rate of 82 ± 4% at 37 °C, mimicking human body conditions. The hydrogel's functionality to store and release the insulin does not compromise its thermo-responsivity and the overall performance of the OECT. This multifunctional OECT opens new avenues for the development of customizable and personalized sensing and drug-delivery systems. |
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