Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition

Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to in-fluence AC concentrations but a better understanding of their biological, lifestyle and metabo...

Descripción completa

Detalles Bibliográficos
Autores: Wedekind, Roland, Rothwell, Joseph A., Viallon, Vivian, Keski Rahkonen, Pekka, Schmidt, Julie A., Chajes, Veronique, Katzke, Verena, Johnson, Theron, Santucci de Magistris, Maria, Krogh, Vittorio, Amiano, Pilar, Sacerdote, Carlotta, Redondo Sánchez, Daniel, Huerta, José María, Tjønneland, Anne, Pokharel, Pratik, Jakszyn, Paula, Tumino, Rosario, Ardanaz, Eva, Sandanger, Torkjel M., Winkvist, Anna, Hultdin, Johan, Schulze, Matthias B., Weiderpass, Elisabete, Gunter, Marc J., Huybrechts, Inge, Scalbert, Augustin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224141
Acceso en línea:https://hdl.handle.net/2445/224141
Access Level:acceso abierto
Palabra clave:Àcids grassos en la nutrició
Lípids en la nutrició
Lipoproteïnes de la sang
Fatty acids in human nutrition
Lipids in human nutrition
Blood lipoproteins
id ES_4169df397c8d0ec2d8d0473f26b3b15a
oai_identifier_str oai:recercat.cat:2445/224141
network_acronym_str ES
network_name_str España
repository_id_str
spelling Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and NutritionWedekind, RolandRothwell, Joseph A.Viallon, VivianKeski Rahkonen, PekkaSchmidt, Julie A.Chajes, VeroniqueKatzke, VerenaJohnson, TheronSantucci de Magistris, MariaKrogh, VittorioAmiano, PilarSacerdote, CarlottaRedondo Sánchez, DanielHuerta, José MaríaTjønneland, AnnePokharel, PratikJakszyn, PaulaTumino, RosarioArdanaz, EvaSandanger, Torkjel M.Winkvist, AnnaHultdin, JohanSchulze, Matthias B.Weiderpass, ElisabeteGunter, Marc J.Huybrechts, IngeScalbert, AugustinÀcids grassos en la nutricióLípids en la nutricióLipoproteïnes de la sangFatty acids in human nutritionLipids in human nutritionBlood lipoproteinsBackground & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to in-fluence AC concentrations but a better understanding of their biological, lifestyle and metabolic de-terminants is needed. Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed. Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r= 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r= 0.5). Intake of most other foods and of carnitine showed little association with AC levels. Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention. (c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND IGO license (http://creativecommons.org/licenses/by-nc-nd/3.0/igo/).Elsevier2025202520222025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/224141Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.clnu.2022.05.020Clinical Nutrition, 2022, vol. 41, num. 8, p. 1735-1745https://doi.org/10.1016/j.clnu.2022.05.020cc-by-nc-nd (c) Elsevier, 2022http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2241412026-05-29T05:05:01Z
dc.title.none.fl_str_mv Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
title Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
spellingShingle Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
Wedekind, Roland
Àcids grassos en la nutrició
Lípids en la nutrició
Lipoproteïnes de la sang
Fatty acids in human nutrition
Lipids in human nutrition
Blood lipoproteins
title_short Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
title_full Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
title_fullStr Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
title_full_unstemmed Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
title_sort Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
dc.creator.none.fl_str_mv Wedekind, Roland
Rothwell, Joseph A.
Viallon, Vivian
Keski Rahkonen, Pekka
Schmidt, Julie A.
Chajes, Veronique
Katzke, Verena
Johnson, Theron
Santucci de Magistris, Maria
Krogh, Vittorio
Amiano, Pilar
Sacerdote, Carlotta
Redondo Sánchez, Daniel
Huerta, José María
Tjønneland, Anne
Pokharel, Pratik
Jakszyn, Paula
Tumino, Rosario
Ardanaz, Eva
Sandanger, Torkjel M.
Winkvist, Anna
Hultdin, Johan
Schulze, Matthias B.
Weiderpass, Elisabete
Gunter, Marc J.
Huybrechts, Inge
Scalbert, Augustin
author Wedekind, Roland
author_facet Wedekind, Roland
Rothwell, Joseph A.
Viallon, Vivian
Keski Rahkonen, Pekka
Schmidt, Julie A.
Chajes, Veronique
Katzke, Verena
Johnson, Theron
Santucci de Magistris, Maria
Krogh, Vittorio
Amiano, Pilar
Sacerdote, Carlotta
Redondo Sánchez, Daniel
Huerta, José María
Tjønneland, Anne
Pokharel, Pratik
Jakszyn, Paula
Tumino, Rosario
Ardanaz, Eva
Sandanger, Torkjel M.
Winkvist, Anna
Hultdin, Johan
Schulze, Matthias B.
Weiderpass, Elisabete
Gunter, Marc J.
Huybrechts, Inge
Scalbert, Augustin
author_role author
author2 Rothwell, Joseph A.
Viallon, Vivian
Keski Rahkonen, Pekka
Schmidt, Julie A.
Chajes, Veronique
Katzke, Verena
Johnson, Theron
Santucci de Magistris, Maria
Krogh, Vittorio
Amiano, Pilar
Sacerdote, Carlotta
Redondo Sánchez, Daniel
Huerta, José María
Tjønneland, Anne
Pokharel, Pratik
Jakszyn, Paula
Tumino, Rosario
Ardanaz, Eva
Sandanger, Torkjel M.
Winkvist, Anna
Hultdin, Johan
Schulze, Matthias B.
Weiderpass, Elisabete
Gunter, Marc J.
Huybrechts, Inge
Scalbert, Augustin
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Àcids grassos en la nutrició
Lípids en la nutrició
Lipoproteïnes de la sang
Fatty acids in human nutrition
Lipids in human nutrition
Blood lipoproteins
topic Àcids grassos en la nutrició
Lípids en la nutrició
Lipoproteïnes de la sang
Fatty acids in human nutrition
Lipids in human nutrition
Blood lipoproteins
description Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to in-fluence AC concentrations but a better understanding of their biological, lifestyle and metabolic de-terminants is needed. Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed. Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r= 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r= 0.5). Intake of most other foods and of carnitine showed little association with AC levels. Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention. (c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND IGO license (http://creativecommons.org/licenses/by-nc-nd/3.0/igo/).
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/224141
url https://hdl.handle.net/2445/224141
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2022.05.020
Clinical Nutrition, 2022, vol. 41, num. 8, p. 1735-1745
https://doi.org/10.1016/j.clnu.2022.05.020
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2022
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406844768747520
score 15,812429

Similares en LA Referencia