Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke

Introduction: Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, longterm biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality...

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Bibliographic Details
Authors: Lázaro, Iolanda, Luján Barroso, Leila, Soldevila Domenech, Natalia, Amor, Antonio J., Ortega, Emilio, Ros, Emilio, Sánchez, María José, Rodríguez Barranco, Miguel, Guevara, Marcela, Moreno ribas, Conchi, Schröder, Helmut, Fitó, Montserrat, Tintle, Nathan L., Ryder, Nathan, Harris, William S., Agudo, Antonio, Sala Vila, Aleix
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::3c44b6ebf92f1f87ffcb33a9a086bf55
Online Access:https://hdl.handle.net/2445/228784
Access Level:Open access
Keyword:Àcids grassos en la nutrició
Metabolisme dels lípids
Malalties cerebrovasculars
Fatty acids in human nutrition
Lipid metabolism
Cerebrovascular disease
Description
Summary:Introduction: Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, longterm biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality (LFQ) score considering pre-defined RBC-FA diet-related biomarkers, and examined whether LFQ score relates to the risk of ischemic stroke. Patients and methods: We determined the RBC-FAs (n = 438 cases of incident ischemic stroke, n= 438 matched controls). For each participant, we scored 1 for each beneficial metric (C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3) >= the median of the control group; and 1 for each detrimental metric (C16:0; C16:1n-7; C18:0) < the median of the control group. LFQ score resulted from the 8-component sum (range = 0-8; higher values, higher fat quality). We explored the validity of findings in a different background (n = 2468 participants from the Framingham Offspring Study without ischemic stroke at baseline, 12-year median follow-up, n= 121 cases). Results: In a fully adjusted model, the Odds Ratio (OR) for ischemic stroke was 0.86 (95% confidence interval [CI] = 0.77-0.95) for each 1-unit increase of the LFQ score. Compared to individuals at the lowest category of LFQ score (0-3 points), those at the top category (5-8 points) had lower odds (OR = 0.64, 95% CI = 0.44-0.94). The findings were similar in the Framingham Offspring Study (Hazard Ratio [HR] for each 1-unit increase = 0.83; 95% CI = 0.70-0.99; HR for those at top category = 0.49; 95% CI = 0.29-0.84, compared to those at the lowest category). Conclusion: Low blood-based LFQ scores relate to a high risk of ischemic stroke.

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