Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging

The combination of different bioimaging techniques, mainly in the field of oncology, allows circumventing the defects associated with the individual imaging modalities, thus providing a more reliable diagnosis. The development of multimodal endogenous probes that are simultaneously suitable for vari...

Descripción completa

Detalles Bibliográficos
Autores: González-Mancebo, Daniel, Becerro, Ana Isabel, Corral, Ariadna, García-Embid, Sonia, Balcerzyk, Marcin, García-Martín, María L., Fuente, Jesús M. de la, Ocaña, Manuel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/216703
Acceso en línea:http://hdl.handle.net/10261/216703
Access Level:acceso abierto
Palabra clave:Lanthanide nanoparticles
Trimodal
High field MRI
Dual energy CT
Luminescence
id ES_40cf5acc4e2d6675ad515be4ccdfeb3c
oai_identifier_str oai:digital.csic.es:10261/216703
network_acronym_str ES
network_name_str España
repository_id_str
spelling Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imagingGonzález-Mancebo, DanielBecerro, Ana IsabelCorral, AriadnaGarcía-Embid, SoniaBalcerzyk, MarcinGarcía-Martín, María L.Fuente, Jesús M. de laOcaña, ManuelLanthanide nanoparticlesTrimodalHigh field MRIDual energy CTLuminescenceThe combination of different bioimaging techniques, mainly in the field of oncology, allows circumventing the defects associated with the individual imaging modalities, thus providing a more reliable diagnosis. The development of multimodal endogenous probes that are simultaneously suitable for various imaging modalities, such as magnetic resonance imaging (MRI), X-ray computed tomography (CT) and luminescent imaging (LI) is, therefore, highly recommended. Such probes should operate in the conditions imposed by the newest imaging equipment, such as MRI operating at high magnetic fields and dual-energy CT. They should show, as well, high photoluminescence emission intensity for their use in optical imaging and present good biocompatibility. In this context, we have designed a single nanoprobe, based on a core-shell architecture, composed of a luminescent Eu:BaLuF core surrounded by an external HoF shell that confers the probe with very high magnetic transverse relaxivity at high field. An intermediate, optically inert BaLuF layer was interposed between the core and the shell to hinder Eu–Ho cross-relaxation and avoid luminescence quenching. The presence of Ba and Lu, with different K-edges, allows for good X-ray attenuation at high and low voltages. The core-shell nanoparticles synthesized are good potential candidates as trimodal bioprobes for MRI at high field, dual-energy CT and luminescent imaging.This research was funded by the Spanish Ministry of Science, Innovation, and Universities (RTI2018-094426-B-I00). Siemens Healthcare S.L.U. also supported part of the research. We also acknowledge the use of the CNA’s ICTS NanoCT facilities and support from DGA and Fondos Feder for funding Bionanosurf (E15_17R) research group. S. Garcia-Embid acknowledges the Ministerio de Educación, Cultura y Deportes of Spanish Government for a FPU grant (FPU15/04482).ElsevierAgencia Estatal de Investigación (España)Ministerio de Educación, Cultura y Deporte (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionDiputación General de AragónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/216703reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094426-B-I00RTI2018-094426-B-I00/AEI/10.13039/501100011033http://dx.doi.org/10.1016/j.jcis.2020.03.101Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2167032026-05-22T06:33:51Z
dc.title.none.fl_str_mv Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
title Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
spellingShingle Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
González-Mancebo, Daniel
Lanthanide nanoparticles
Trimodal
High field MRI
Dual energy CT
Luminescence
title_short Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
title_full Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
title_fullStr Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
title_full_unstemmed Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
title_sort Design of a nanoprobe for high field magnetic resonance imaging, dual energy X-ray computed tomography and luminescent imaging
dc.creator.none.fl_str_mv González-Mancebo, Daniel
Becerro, Ana Isabel
Corral, Ariadna
García-Embid, Sonia
Balcerzyk, Marcin
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author González-Mancebo, Daniel
author_facet González-Mancebo, Daniel
Becerro, Ana Isabel
Corral, Ariadna
García-Embid, Sonia
Balcerzyk, Marcin
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author_role author
author2 Becerro, Ana Isabel
Corral, Ariadna
García-Embid, Sonia
Balcerzyk, Marcin
García-Martín, María L.
Fuente, Jesús M. de la
Ocaña, Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Educación, Cultura y Deporte (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Diputación General de Aragón
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lanthanide nanoparticles
Trimodal
High field MRI
Dual energy CT
Luminescence
topic Lanthanide nanoparticles
Trimodal
High field MRI
Dual energy CT
Luminescence
description The combination of different bioimaging techniques, mainly in the field of oncology, allows circumventing the defects associated with the individual imaging modalities, thus providing a more reliable diagnosis. The development of multimodal endogenous probes that are simultaneously suitable for various imaging modalities, such as magnetic resonance imaging (MRI), X-ray computed tomography (CT) and luminescent imaging (LI) is, therefore, highly recommended. Such probes should operate in the conditions imposed by the newest imaging equipment, such as MRI operating at high magnetic fields and dual-energy CT. They should show, as well, high photoluminescence emission intensity for their use in optical imaging and present good biocompatibility. In this context, we have designed a single nanoprobe, based on a core-shell architecture, composed of a luminescent Eu:BaLuF core surrounded by an external HoF shell that confers the probe with very high magnetic transverse relaxivity at high field. An intermediate, optically inert BaLuF layer was interposed between the core and the shell to hinder Eu–Ho cross-relaxation and avoid luminescence quenching. The presence of Ba and Lu, with different K-edges, allows for good X-ray attenuation at high and low voltages. The core-shell nanoparticles synthesized are good potential candidates as trimodal bioprobes for MRI at high field, dual-energy CT and luminescent imaging.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/216703
url http://hdl.handle.net/10261/216703
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094426-B-I00
RTI2018-094426-B-I00/AEI/10.13039/501100011033
http://dx.doi.org/10.1016/j.jcis.2020.03.101
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406782477041664
score 15,81155

Similares en LA Referencia