Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjec...

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Detalles Bibliográficos
Autores: Sans-de San Nicolàs, Lídia|||0000-0002-2828-2842, Figueras-Nart, Ignasi|||0000-0001-9341-5923, García-Jiménez, Irene|||0000-0002-1769-354X, Bonfill-Ortí, Montserrat, Guilabert, Antonio, Curto-Barredo, Laia|||0000-0002-7387-4257, Bertolin Colilla, Marta|||0000-0002-2514-3230, Ferran, Marta|||0000-0003-1198-0641, Serra Baldrich, Esther|||0000-0001-7603-0300, Pujol Vallverdú, Ramón M.|||0000-0002-5622-6055, Santamaria-Babí, Luis F.|||0000-0002-1674-6654
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280934
Acceso en línea:https://ddd.uab.cat/record/280934
https://dx.doi.org/urn:doi:10.3389/fimmu.2023.1124018
Access Level:acceso abierto
Palabra clave:Atopic dermatitis
CCL27
CLA + memory T cells
House dust mite
IgE
IL-31
Periostin
Pruritus
Descripción
Sumario:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. HDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels.

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