Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population

Insulin resistance (IR) is a central feature in the pathophysiology of type 2 diabetes and a major determinant of cardiovascular morbidity. While sociodemographic and lifestyle factors are established contributors, the role of social isolation as a potential determinant of IR remains underexplored i...

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Autores: Riutord-Sbert, Pere, Tárraga López, Pedro Juan, López-González, Ángel Arturo, Coll Campayo, Irene, Busquets-Cortés, Carla, Ramírez-Manent, José Ignacio
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25952
Acceso en línea:https://hdl.handle.net/20.500.13003/25952
Access Level:acceso abierto
Palabra clave:Diet, Mediterranean
Insulin Resistance
Social Isolation
Dieta Mediterránea
Resistencia a la Insulina
Aislamiento Social
Mediterranean diet
TyG indez
insulin resistance
physical activity
social isolation
sociodemographic variables
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spelling Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working PopulationRiutord-Sbert, PereTárraga López, Pedro JuanLópez-González, Ángel ArturoColl Campayo, IreneBusquets-Cortés, CarlaRamírez-Manent, José IgnacioDiet, MediterraneanInsulin ResistanceSocial IsolationDieta MediterráneaResistencia a la InsulinaAislamiento SocialMediterranean dietTyG indezinsulin resistancephysical activitysocial isolationsociodemographic variablesInsulin resistance (IR) is a central feature in the pathophysiology of type 2 diabetes and a major determinant of cardiovascular morbidity. While sociodemographic and lifestyle factors are established contributors, the role of social isolation as a potential determinant of IR remains underexplored in working populations. To assess the association between sociodemographic variables, lifestyle habits, and social isolation with three validated insulin resistance indexes-Triglyceride-Glucose (TyG), Metabolic Score for Insulin Resistance (METS-IR), and Single Point Insulin Sensitivity Estimator (SPISE-IR)-in a large cohort of Spanish workers. A cross-sectional study was conducted involving 117,298 workers from occupational health centers across Spain. Sociodemographic data, lifestyle factors (Mediterranean diet adherence, physical activity, and smoking), and social support levels (ENRICHD Social Support Instrument) were recorded. Biochemical and anthropometric parameters were obtained through standardized protocols. Logistic regression models estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for high IR risk across the three indexes, adjusting for potential confounders. Male sex, older age, lower social class, smoking, low Mediterranean diet adherence, physical inactivity, and low social support were independently associated with higher odds of IR in all three indexes. The strongest associations were observed for physical inactivity (OR range 6.21-9.95) and low social support (OR range 1.98-3.76). Although effect sizes varied by index, patterns of association were consistent. Sociodemographic, lifestyle, and psychosocial factors, including social isolation, are strongly associated with insulin resistance in working populations. Integrating social support assessment into occupational health strategies may enhance early detection and prevention of IR and related cardiometabolic diseases.MDPI20252025-09-0320252025-09-03research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25952reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/259522026-06-22T12:44:07Z
dc.title.none.fl_str_mv Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
title Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
spellingShingle Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
Riutord-Sbert, Pere
Diet, Mediterranean
Insulin Resistance
Social Isolation
Dieta Mediterránea
Resistencia a la Insulina
Aislamiento Social
Mediterranean diet
TyG indez
insulin resistance
physical activity
social isolation
sociodemographic variables
title_short Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
title_full Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
title_fullStr Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
title_full_unstemmed Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
title_sort Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
dc.creator.none.fl_str_mv Riutord-Sbert, Pere
Tárraga López, Pedro Juan
López-González, Ángel Arturo
Coll Campayo, Irene
Busquets-Cortés, Carla
Ramírez-Manent, José Ignacio
author Riutord-Sbert, Pere
author_facet Riutord-Sbert, Pere
Tárraga López, Pedro Juan
López-González, Ángel Arturo
Coll Campayo, Irene
Busquets-Cortés, Carla
Ramírez-Manent, José Ignacio
author_role author
author2 Tárraga López, Pedro Juan
López-González, Ángel Arturo
Coll Campayo, Irene
Busquets-Cortés, Carla
Ramírez-Manent, José Ignacio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Diet, Mediterranean
Insulin Resistance
Social Isolation
Dieta Mediterránea
Resistencia a la Insulina
Aislamiento Social
Mediterranean diet
TyG indez
insulin resistance
physical activity
social isolation
sociodemographic variables
topic Diet, Mediterranean
Insulin Resistance
Social Isolation
Dieta Mediterránea
Resistencia a la Insulina
Aislamiento Social
Mediterranean diet
TyG indez
insulin resistance
physical activity
social isolation
sociodemographic variables
description Insulin resistance (IR) is a central feature in the pathophysiology of type 2 diabetes and a major determinant of cardiovascular morbidity. While sociodemographic and lifestyle factors are established contributors, the role of social isolation as a potential determinant of IR remains underexplored in working populations. To assess the association between sociodemographic variables, lifestyle habits, and social isolation with three validated insulin resistance indexes-Triglyceride-Glucose (TyG), Metabolic Score for Insulin Resistance (METS-IR), and Single Point Insulin Sensitivity Estimator (SPISE-IR)-in a large cohort of Spanish workers. A cross-sectional study was conducted involving 117,298 workers from occupational health centers across Spain. Sociodemographic data, lifestyle factors (Mediterranean diet adherence, physical activity, and smoking), and social support levels (ENRICHD Social Support Instrument) were recorded. Biochemical and anthropometric parameters were obtained through standardized protocols. Logistic regression models estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for high IR risk across the three indexes, adjusting for potential confounders. Male sex, older age, lower social class, smoking, low Mediterranean diet adherence, physical inactivity, and low social support were independently associated with higher odds of IR in all three indexes. The strongest associations were observed for physical inactivity (OR range 6.21-9.95) and low social support (OR range 1.98-3.76). Although effect sizes varied by index, patterns of association were consistent. Sociodemographic, lifestyle, and psychosocial factors, including social isolation, are strongly associated with insulin resistance in working populations. Integrating social support assessment into occupational health strategies may enhance early detection and prevention of IR and related cardiometabolic diseases.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-09-03
2025
2025-09-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/25952
url https://hdl.handle.net/20.500.13003/25952
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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