Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention

Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglyc...

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Autores: García-Cordero, Joaquín, Mateos, Raquel, González-Rámila, Susana, Seguido, Miguel A., Sierra-Cinos, José Luis, Sarriá, Beatriz, Bravo-Clemente, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/310509
Acceso en línea:http://hdl.handle.net/10261/310509
Access Level:acceso abierto
Palabra clave:Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
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spelling Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle interventionGarcía-Cordero, JoaquínMateos, RaquelGonzález-Rámila, SusanaSeguido, Miguel A.Sierra-Cinos, José LuisSarriá, BeatrizBravo-Clemente, LauraOat beta-glucanGreen coffee hydroxycinnamatesObesityLipid metabolismGlucose homeostasisObesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.This research was funded by project AGL2015-69986-R from the Spanish Ministry of Economy and Competitivity. J.G.-C. had a predoctoral grant funded by Comunidad de Madrid (PEJD-2017-PRE_BIO-4225). M.A.S. had a predoctoral contract funded by Comunidad de Madrid (PEJD-2018-PRE/SAL-9104). S.G.-R. had a predoctoral contract funded by Interprofesional del Aceite de Orujo de Oliva (ORIVA).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Comunidad de MadridInterprofesional del Aceite de Orujo de OlivaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/310509reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//AGL2015-69986-RPEJD-2017-PRE/BIO-4225/InvestigadoresPredoctoralesPEJD-2018-PRE/SAL-9104/InvestigadoresPredoctoralesThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/nu15092223https://doi.org/10.3390/nu15092223Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3105092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
title Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
spellingShingle Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
García-Cordero, Joaquín
Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
title_short Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
title_full Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
title_fullStr Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
title_full_unstemmed Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
title_sort Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention
dc.creator.none.fl_str_mv García-Cordero, Joaquín
Mateos, Raquel
González-Rámila, Susana
Seguido, Miguel A.
Sierra-Cinos, José Luis
Sarriá, Beatriz
Bravo-Clemente, Laura
author García-Cordero, Joaquín
author_facet García-Cordero, Joaquín
Mateos, Raquel
González-Rámila, Susana
Seguido, Miguel A.
Sierra-Cinos, José Luis
Sarriá, Beatriz
Bravo-Clemente, Laura
author_role author
author2 Mateos, Raquel
González-Rámila, Susana
Seguido, Miguel A.
Sierra-Cinos, José Luis
Sarriá, Beatriz
Bravo-Clemente, Laura
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Interprofesional del Aceite de Orujo de Oliva
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
topic Oat beta-glucan
Green coffee hydroxycinnamates
Obesity
Lipid metabolism
Glucose homeostasis
description Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/310509
url http://hdl.handle.net/10261/310509
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//AGL2015-69986-R
PEJD-2017-PRE/BIO-4225/InvestigadoresPredoctorales
PEJD-2018-PRE/SAL-9104/InvestigadoresPredoctorales
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/nu15092223
https://doi.org/10.3390/nu15092223
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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