Rev1 wbdR tagged vaccines against Brucella ovis

Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B....

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Autores: Aragón-Aranda, Beatriz, De Miguel, María Jesús, Martínez-Gómez, Estrella, Zúñiga-Ripa, Amaia, Salvador-Bescós, Miriam, Moriyón, Ignacio, Iriarte, Maite, Muñoz, Pilar M., Conde-Álvarez, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:87634
Acceso en línea:http://zaguan.unizar.es/record/87634
Access Level:acceso abierto
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spelling Rev1 wbdR tagged vaccines against Brucella ovisAragón-Aranda, BeatrizDe Miguel, María JesúsMartínez-Gómez, EstrellaZúñiga-Ripa, AmaiaSalvador-Bescós, MiriamMoriyón, IgnacioIriarte, MaiteMuñoz, Pilar M.Conde-Álvarez, RaquelSheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/87634reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-Rinfo:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609info:eu-repo/semantics/openAccessoai:zaguan.unizar.es:876342026-05-29T13:59:51Z
dc.title.none.fl_str_mv Rev1 wbdR tagged vaccines against Brucella ovis
title Rev1 wbdR tagged vaccines against Brucella ovis
spellingShingle Rev1 wbdR tagged vaccines against Brucella ovis
Aragón-Aranda, Beatriz
title_short Rev1 wbdR tagged vaccines against Brucella ovis
title_full Rev1 wbdR tagged vaccines against Brucella ovis
title_fullStr Rev1 wbdR tagged vaccines against Brucella ovis
title_full_unstemmed Rev1 wbdR tagged vaccines against Brucella ovis
title_sort Rev1 wbdR tagged vaccines against Brucella ovis
dc.creator.none.fl_str_mv Aragón-Aranda, Beatriz
De Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
author Aragón-Aranda, Beatriz
author_facet Aragón-Aranda, Beatriz
De Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
author_role author
author2 De Miguel, María Jesús
Martínez-Gómez, Estrella
Zúñiga-Ripa, Amaia
Salvador-Bescós, Miriam
Moriyón, Ignacio
Iriarte, Maite
Muñoz, Pilar M.
Conde-Álvarez, Raquel
author2_role author
author
author
author
author
author
author
author
description Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/87634
url http://zaguan.unizar.es/record/87634
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-R
info:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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